Evidence map›Paper›PMID 30992019›Full record

ArticleVirology journal2019

Hepatitis C screening in hospitals: find the missing patients.

Lili Liu, Hongqin Xu, Yue Hu, Jia Shang, Jianning Jiang, Lei Yu, Caiyan Zhao, Dazhi Zhang, Xinxin Zhang, Junfeng Li and 11 more

Abstract read
In one paragraph

Article in Virology journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Article
  3. [Analysis of the results of the Fuxing Program Action for micro-elimination of hepatitis C in Zhuhai].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2025
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. [Analysis of the factors influencing the elimination strategies with the current status of diagnosis and treatment of hepatitis C in hospital].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2021
    Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Hepatitis C virus micro-elimination: Where do we stand?World journal of gastroenterology · 2021
    Review
  19. [In-hospital process for viral hepatitis C screening and management in China (Draft)].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2021
    Article
  20. [Establishment and implementation of hepatitis C screening and referral channels in the hospitals].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Lili LiuDepartment of Hepatology, The First Hospital of Jilin University, Changchun, Jilin, 130021, China.
Hongqin XuDepartment of Hepatology, The First Hospital of Jilin University, Changchun, Jilin, 130021, China.
Yue HuDepartment of Phase I Clinical trial Center, The First Hospital of Jilin University, Changchun, Jilin, 130021, China.
Jia ShangDepartment of Infectious Disease, Henan Provincial People's Hospital, Zhengzhou, Henan, 450003, China.
Jianning JiangDepartment of Infectious Disease, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, China.
Lei YuDepartment of Infectious Disease, The Fourth Hospital of Harbin Medical University, Harbin, Heilongjiang, 150001, China.
Caiyan ZhaoDepartment of Infectious Disease, The Third Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050051, China.
Dazhi ZhangDepartment of Infectious Diseases, Institute of Viral Hepatitis, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
Xinxin ZhangDepartment of Infectious Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China.
Junfeng LiDepartment of Infectious Diseases, The First Hospital of Lanzhou University, Lanzhou, Gansu, 730000, China.
Wei LiDepartment of Infectious Disease, Henan Provincial People's Hospital, Zhengzhou, Henan, 450003, China.
Yanan WuDepartment of Infectious Disease, Henan Provincial People's Hospital, Zhengzhou, Henan, 450003, China.
Diefei HuDepartment of Infectious Disease, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, China.
Xiaofang WangDepartment of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 31000, China.
Qian ZhaoDepartment of Infectious Disease, The Third Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050051, China.
Qiongfang ZhangDepartment of Infectious Diseases, Institute of Viral Hepatitis, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
Wenqiang LuoDepartment of Infectious Diseases, Institute of Viral Hepatitis, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
Jia ChenDepartment of Infectious Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China.
Donghua ZhangDepartment of Infectious Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China.
Wei ZhouDepartment of Infectious Diseases, The First Hospital of Lanzhou University, Lanzhou, Gansu, 730000, China.
Junqi NiuDepartment of Hepatology, The First Hospital of Jilin University, Changchun, Jilin, 130021, China. junqi_niu@163.com.ORCID 0000-0002-5187-7297

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHepatitis C virus (HCV) infection is one of the leading causes of liver cancer, creating enormous economic and social burdens. The Chinese government recommends routine screening of inpatients for HCV before invasive procedures to prevent iatric infections. However, the diagnosis and treatment rates for HCV remain low. The aim of this study was to use available routine screening data to understand the HCV screening of inpatients in different regions of China.

methodsInpatient information and HCV screening results were collected from January 2016 to December 2016 at eight tertiary hospitals in different regions of China to compare the HCV-positivity of hospitalized patients among different regions and age groups.

resultsThe HCV screening rate of inpatients was more than 50%. A total of 467,008 inpatients were enrolled in the study (51.20% were male), and the HCV antibody (anti-HCV) -positive rate was 0.88% (95% confidence interval [CI], 0.85-0.91%) among the total population. This rate was significantly higher among all males compared with all females (0.91% vs 0.85%). Moreover, the HCV antibody-positive rate increased with age and was highest for the 60-64-year age group. Notably, 90.14% (3722/4129) of the anti-HCV seropositive patients were 40 years of age or older. HCV screening for people over 40 years old is recommended.

conclusionsThis study highlights the key role of routine examination for HCV infection in hospitalized patients. Full use of inpatient screening results to manage HCV antibody-positive patients and a screening strategy targeting inpatients 40 years and older were found to be low-cost and effective, which will help to find the missing millions of yet unaware patients and also accelerate the elimination of HCV in China.

Indexed as

AdolescentAdultAgedChildChild, PreschoolFemaleHepatitis BHepatitis CHepatitis C AntibodiesHospitalizationHospitalsHumansInfantInfant, NewbornLiver NeoplasmsMaleHepatitis C AntibodiesHepatitis C virusHospitalPositive rateScreening

Identifiers

PMID30992019
PMCPMC6469068

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.