Evidence map›Paper›PMID 30991709›Full record

ArticleCells2019

NFκB- and MAP-Kinase Signaling Contribute to the Activation of Murine Myeloid Dendritic Cells by a Flagellin A:Allergen Fusion Protein.

Tobias Moeller, Sonja Wolfheimer, Alexandra Goretzki, Stephan Scheurer, Stefan Schülke

Open access · goldAbstract read
In one paragraph

Article in Cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
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  11. Stories From the Dendritic Cell Guardhouse.Frontiers in immunology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Tobias MoellerPaul-Ehrlich-Institut, Vice President´s Research Group 1: Molecular Allergology; 63225 Langen (Hesse), Germany. tobias.moeller1990@gmx.de.
Sonja WolfheimerPaul-Ehrlich-Institut, Vice President´s Research Group 1: Molecular Allergology; 63225 Langen (Hesse), Germany. Sonja.Wolfheimer@pei.de.
Alexandra GoretzkiPaul-Ehrlich-Institut, Vice President´s Research Group 1: Molecular Allergology; 63225 Langen (Hesse), Germany. Alexandra.Goretzki@pei.de.
Stephan ScheurerPaul-Ehrlich-Institut, Vice President´s Research Group 1: Molecular Allergology; 63225 Langen (Hesse), Germany. Stephan.Scheurer@pei.de.ORCID 0000-0002-2859-562X
Stefan SchülkePaul-Ehrlich-Institut, Vice President´s Research Group 1: Molecular Allergology; 63225 Langen (Hesse), Germany. stefan.schuelke@pei.de.
Paul Ehrlich Institut · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fusion proteins incorporating the TLR5-ligand flagellin are currently undergoing clinical trials as vaccine candidates for many diseases. We recently reported a flagellin:allergen fusion protein containing the TLR5-ligand flagellin A (FlaA) from

Indexed as

AnimalsAntigens, PlantCytokinesDendritic CellsDrug HypersensitivityFlagellinInterleukin-10MAP Kinase Signaling SystemMiceMice, Inbred BALB CMitogen-Activated Protein KinasesMyeloid CellsNF-kappa BRecombinant Fusion ProteinsTOR Serine-Threonine KinasesVaccinesAntigens, PlantBet v 1 allergen, BetulaCytokinesFlagellinInterleukin-10Mitogen-Activated Protein KinasesNF-kappa BRecombinant Fusion ProteinsTOR Serine-Threonine KinasesVaccinesBet v 1birch allergyflagellinfusion proteinMAPKmetabolismNF?BsignallingTLR5vaccine

Identifiers

PMID30991709
PMCPMC6523117
OpenAlexW2940168990

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.