Evidence map›Paper›PMID 30991693›Full record

ArticleCancers2019

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Induces Intracellular Ca

Pawan Faris, Giorgia Pellavio, Federica Ferulli, Francesca Di Nezza, Mudhir Shekha, Dmitry Lim, Marcello Maestri, Germano Guerra, Luigi Ambrosone, Paolo Pedrazzoli and 3 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 46 citations in OpenAlex.

  1. The CaInternational journal of molecular sciences · 2026
    Article
  2. Article
  3. Whole-exome sequencing identifies cancer-associated variants of the endo-lysosomal ion transport channels in the Saudi population.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024
    Article
  4. Article
  5. Lysosomal TRPML1 triggers global CaFrontiers in physiology · 2024
    Article
  6. Article
  7. Article
  8. Review
  9. TRPML1-Induced Lysosomal CaInternational journal of molecular sciences · 2023
    Article
  10. NAADP-Mediated CaHandbook of experimental pharmacology · 2023
    Article
  11. Intracellular CaFrontiers in physiology · 2023
    Review
  12. Article
  13. Article
  14. Article
  15. Nicotinic Acid Adenine Dinucleotide Phosphate Induces Intracellular CaFrontiers in cell and developmental biology · 2022
    Article
  16. Targeting the two-pore channel 2 in cancer progression and metastasis.Exploration of targeted anti-tumor therapy · 2022
    Review
  17. Article
  18. Reactive Oxygen Species and Endothelial CaInternational journal of molecular sciences · 2021
    Review
  19. Review
  20. The human amniotic fluid stem cell secretome triggers intracellular CaJournal of cellular and molecular medicine · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Pawan FarisLaboratory of General Physiology, Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, 27100 Pavia, Italy. pawan.faris@yahoo.com.ORCID 0000-0001-6867-0359
Giorgia PellavioHuman Physiology Unit, via Forlanini 6, Department of Molecular Medicine, University of Pavia, 27100 Pavia, Italy. giorgia.pellavio01@universitadipavia.it.
Federica FerulliLaboratory of Immunology Transplantation, Foundation IRCCS Policlinico San Matteo, 27100 Pavia, Italy. federica.ferulli@gmail.com.
Francesca Di NezzaDepartment of Medicine and Health Sciences "Vincenzo Tiberio", University of Molise, 86100 Campobasso, Italy. francesca.dinezza@gmail.com.
Mudhir ShekhaResearch Centre, Salahaddin University-Erbil, 44001 Erbil, Kurdistan-Region of Iraq, Iraq. mudhir.shekha@su.edu.krd.ORCID 0000-0002-9552-838X
Dmitry LimDepartment of Pharmaceutical Sciences, Università del Piemonte Orientale, 28100 Novara, Italy. dmitry.lim@uniupo.it.ORCID 0000-0002-4316-2654
Marcello MaestriUnit of General Surgery, Foundation IRCCS Policlinico San Matteo, 27100 Pavia, Italy. mmaestri@smatteo.pv.it.
Germano GuerraDepartment of Medicine and Health Sciences "Vincenzo Tiberio", University of Molise, 86100 Campobasso, Italy. germano.guerra@unimol.it.
Luigi AmbrosoneDepartment of Medicine and Health Sciences "Vincenzo Tiberio", University of Molise, 86100 Campobasso, Italy. ambroson@unimol.it.
Paolo PedrazzoliMedical Oncology, oundation IRCCS Policlinico San Matteo, 27100 Pavia, Italy. p.pedrazzoli@smatteo.pv.it.
Umberto LaforenzaHuman Physiology Unit, via Forlanini 6, Department of Molecular Medicine, University of Pavia, 27100 Pavia, Italy. lumberto@unipv.it.ORCID 0000-0003-2951-5983
Daniela MontagnaLaboratory of Immunology Transplantation, Foundation IRCCS Policlinico San Matteo, 27100 Pavia, Italy. d.montagna@smatteo.pv.it.
Francesco MocciaLaboratory of General Physiology, Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, 27100 Pavia, Italy. francesco.moccia@unipv.it.ORCID 0000-0003-0010-0098
University of Pavia · ITUniversity of Molise · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITPoliclinico San Matteo Fondazione · ITUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro” · ITUniversity of Kurdistan Hewler · IQ

Funding

Fondazione IRCCS Policlinico San Matteo RC/08059815BFondazione IRCCS Policlinico San Matteo RF-2011-02352315Ministero della Salute RF-2010-2316319Ministero dell'Istruzione, dell'Università e della Ricerca Dipartimenti di Eccellenza Program (2018-2022) - Dept. of Biology and Biotechnology "L. Spallanzani"Università degli Studi di Pavia Fondo Ricerca Giovani
6 · The paper itself

Abstract

Nicotinic acid adenine dinucleotide phosphate (NAADP) gates two-pore channels 1 and 2 (TPC1 and TPC2) to elicit endo-lysosomal (EL) Ca

Indexed as

cancercolorectal carcinomalysosomal Ca2+ signallingNAADPproliferationTPC1

Identifiers

PMID30991693
PMCPMC6521149
OpenAlexW2939351210

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.