Importance of Chiral Recognition in Designing Metal-Free Ligands for G-Quadruplex DNA.

Dora M Răsădean, Samuel W O Harrison, Isobel R Owens, Aucéanne Miramont, Frances M Bromley, G Dan Pantoș

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

The Influence of Chirality on the β-Amino-Acid Naphthalenediimides/G-Quadruplex DNA Interaction.Molecules (Basel, Switzerland) · 2023
Article
Molecular Recognition of the Hybrid-Type G-Quadruplexes in Human Telomeres.Molecules (Basel, Switzerland) · 2019
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dora M RăsădeanDepartment of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK. D.Rasadean@bath.ac.uk.

Samuel W O HarrisonDepartment of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK. swoharrison@gmail.com.

Isobel R OwensDepartment of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK. isobelowens1@gmail.com.

Aucéanne MiramontDepartment of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK. a.miramont@escom.fr.

Frances M BromleyDepartment of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK. francesbromley95@gmail.com.

G Dan PantoșDepartment of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK. g.d.pantos@bath.ac.uk.ORCID 0000-0003-2200-550X

Funding

EPSRC EB-BB1250University of Bath n/a

6 · The paper itself

Abstract

Four pairs of amino acid-functionalized naphthalenediimide enantiomers (d- and l-lysine derived NDIs) were screened toward G-quadruplex forming sequences in telomeres (h-TELO) and oncogene promoters: c-KIT1, c-KIT2, k-RAS and BCL-2. This is the first study to address the effect of point chirality toward G-quadruplex DNA stabilization using purely small organic molecules. Enantioselective behavior toward the majority of ligands was observed, particularly in the case of parallel conformations of c-KIT2 and k-RAS. Additionally,

Indexed as

G-QuadruplexesDNAHumansImidesNaphthalenesOncogenesTelomereDNAImidesnaphthalenediimideNaphthaleneschiralitychiral recognitioncircular dichroismenantioselectivityG-quadruplex DNA

Identifiers

PMID30991655

DOI10.3390/molecules24081473

PMCPMC6514905

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