Evidence map›Paper›PMID 30991446›Full record

ReviewHepatology (Baltimore, Md.)2019

Incorporating Weight Loss Medications Into Hepatology Practice for Nonalcoholic Steatohepatitis.

Albert Do, Eric J Kuszewski, Karl A Langberg, Wajahat Z Mehal

Open access · greenAbstract readReview
In one paragraph

Review in Hepatology (Baltimore, Md.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. [Guideline for diagnosis and management of metabolic dysfunction-associated fatty liver disease in primary care (2025)].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2025
    Article
  3. Review
  4. [Cirrhosis recompensation: clinical complications].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2023
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Albert DoSection of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT.ORCID 0000-0002-1980-5197
Eric J KuszewskiVA Connecticut Healthcare System, West Haven, CT.
Karl A LangbergSection of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT.
Wajahat Z MehalSection of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT.ORCID 0000-0001-8481-3671
Yale University · USVA Connecticut Healthcare System · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
TRAINING PROGRAM IN INVESTIGATIVE GASTROENTEROLOGYT32DK007017 · NIDDK · YALE UNIVERSITY · PI Fred Sanford Gorelick, Liza Konnikova · 1986 to 2026
$7.1M
Regulation of Liver Fibrosis by Pyruvate Kinase M2 (PKM2)I01BX003259 · VA · VA CONNECTICUT HEALTHCARE SYSTEM · PI WAJAHAT Zafar MEHAL · 2017 to 2026
–
BLRD VA I01 BX003259NCATS NIH HHS UL1 TR001863NIDDK NIH HHS T32 DK007017NIH HHS T32 DK00701741
6 · The paper itself

Abstract

There is an urgent need for practical approaches to patients with nonalcoholic steatohepatitis (NASH). Total body weight loss (TBWL) is an important approach, as its effects are amplified in the liver, with 10% TBWL resulting in a 50% loss of liver triglycerides and improvement in all aspects of NASH histology. Lifestyle changes are the first step in addressing TBWL, but uncommonly result in the range required to improve liver histology in NASH (7%-10%). Weight loss medications (WLMs) are an effective additional tool because they can provide TBWL in the 7%-10% range, have a well-characterized clinical profile, have clear guidelines, and meet approved criteria for their use (body mass index greater than 27 kg/m

Indexed as

Body Mass IndexBody Weight MaintenanceAnti-Obesity AgentsDiet, Fat-RestrictedDisease ManagementFemaleGastroenterologyHumansLife StyleMaleNon-alcoholic Fatty Liver DiseasePrognosisTreatment OutcomeAnti-Obesity Agents

Identifiers

PMID30991446
PMCPMC6783325
OpenAlexW2936706141

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.