Evidence map›Paper›PMID 30990942›Full record

ArticleAngewandte Chemie (International ed. in English)2019

Unidirectional Presentation of Membrane Proteins in Nanoparticle-Supported Liposomes.

Wen Chen, Yongfei Cai, Qingshan Fu, Bing Chen, Junling Guo, James J Chou

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. SARS-CoV-2 virus-like-particlesNanoscale advances · 2023
    Article
  4. Article
  5. Loureirin B activates GLP-1R and promotes insulin secretion in Ins-1 cells.Journal of cellular and molecular medicine · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Wen ChenDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 250 Longwood Avenue, Boston, MA, 02115, USA.
Yongfei CaiDivision of Molecular Medicine, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, 3 Blackfan Street, Boston, MA, 02115, USA.
Qingshan FuDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 250 Longwood Avenue, Boston, MA, 02115, USA.
Bing ChenDivision of Molecular Medicine, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, 3 Blackfan Street, Boston, MA, 02115, USA.
Junling GuoDepartment of Biomass Science and Engineering, Sichuan University, 24 South Section Yihuan Road, Chengdu, Sichuan, 610065, China.ORCID 0000-0002-2948-880X
James J ChouDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 250 Longwood Avenue, Boston, MA, 02115, USA.ORCID 0000-0002-4442-0344
Harvard University · USBoston Children's Hospital · USSichuan University · CN

Funding

Structure-function studies of the membrane-interacting domains of HIV-1 Env spikeR01AI127193 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI CHEN, BING, HARRISON, STEPHEN COPLAN · 2016 to 2025
$8.4M
Function and mechanism of the HCV p7 channel and its therapeutic potentialR01GM116898 · NIGMS · HARVARD MEDICAL SCHOOL · PI CHOU, JAMES JEIWEN · 2016 to 2019
$1.9M
NIAID NIH HHS R01 AI127193NIGMS NIH HHS R01 GM116898
6 · The paper itself

Abstract

Presentation of membrane proteins to host immune systems has been a challenging problem owing to complexity arising from the poor in vivo stability of the membrane-mimetic media often used for solubilizing the membrane proteins. The use of functionalized, biocompatible nanoparticles as substrates is shown to guide the formation of proteoliposomes, which can present many copies of membrane proteins in a unidirectional manner. The approach was demonstrated to present the membrane-proximal region of the HIV-1 envelope glycoprotein. These nanoparticle-supported liposomes are broadly applicable as membrane antigen vehicles for inducing host immune responses.

Indexed as

HumansLiposomesMembrane ProteinsNanoparticlesLiposomesMembrane ProteinsHIV-1 MPERmembrane antigen presentationnanoparticlesproteoliposome formationunidirectionality

Identifiers

PMID30990942
PMCPMC6660371
OpenAlexW4246403425

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.