Evidence map›Paper›PMID 30990914›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2019

High-Field Detection of Biomarkers with Fast Field-Cycling MRI: The Example of Zinc Sensing.

Markus Bödenler, Kyangwi P Malikidogo, Jean-François Morfin, Christoph Stefan Aigner, Éva Tóth, Célia S Bonnet, Hermann Scharfetter

Abstract read
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Joint multi-field TMagnetic resonance in medicine · 2021
    Article
  4. Fast Ion-Chelate Dissociation Rate forJournal of the American Chemical Society · 2021
    Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Markus BödenlerInstitute of Medical Engineering, Graz University of Technology, Graz, Austria.
Kyangwi P MalikidogoCentre de Biophysique Moléculaire, CNRS, Rue Charles Sadron, 45071, Orléans Cedex 2, France.
Jean-François MorfinCentre de Biophysique Moléculaire, CNRS, Rue Charles Sadron, 45071, Orléans Cedex 2, France.
Christoph Stefan AignerInstitute of Medical Engineering, Graz University of Technology, Graz, Austria.ORCID http://orcid.org/0000-0003-3618-9610
Éva TóthCentre de Biophysique Moléculaire, CNRS, Rue Charles Sadron, 45071, Orléans Cedex 2, France.
Célia S BonnetCentre de Biophysique Moléculaire, CNRS, Rue Charles Sadron, 45071, Orléans Cedex 2, France.ORCID http://orcid.org/0000-0003-0228-8098
Hermann ScharfetterInstitute of Medical Engineering, Graz University of Technology, Graz, Austria.

Funding

Agence Nationale de la Recherche ANR-13-JS07-0007European Cooperation in Science and Technology CA15209H2020 Future and Emerging Technologies 665172
6 · The paper itself

Abstract

Many smart magnetic resonance imaging (MRI) probes provide response to a biomarker based on modulation of their rotational correlation time. The magnitude of such MRI signal changes is highly dependent on the magnetic field and the response decreases dramatically at high fields (>2 T). To overcome the loss of efficiency of responsive probes at high field, with fast-field cycling magnetic resonance imaging (FFC-MRI) we exploit field-dependent information rather than the absolute difference in the relaxation rate measured in the absence and in the presence of the biomarker at a given imaging field. We report here the application of fast field-cycling techniques combined with the use of a molecular probe for the detection of Zn

Indexed as

BiomarkersBiosensing TechniquesCoordination ComplexesElectromagnetic FieldsGadoliniumLigandsLimit of DetectionMagnetic Resonance ImagingMolecular ProbesSerum Albumin, HumanThermodynamicsZincBiomarkersCoordination ComplexesGadoliniumLigandsMolecular ProbesSerum Albumin, HumanZinccontrast agentsfast field-cyclinghigh-field detectionmagnetic resonance imagingmolecular imaging

Identifiers

PMID30990914
PMCPMC6618089

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.