ArticlePLoS computational biology2019
Neural control of body-plan axis in regenerating planaria.
Article in PLoS computational biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 40 citations in OpenAlex.
- Redox-modulated ERK dynamics support wound-dependent tissue formation during early planarian regeneration.iScience · 2026Article
- 4D single-cell spatial transcriptomics reveals dynamic morphogenetic gradients and regenerative domains in planarians.GigaScience · 2026Article
- Mechanistic regulation of planarian shape during growth and degrowth.Development (Cambridge, England) · 2024Article
- Information integration during bioelectric regulation of morphogenesis of the embryonic frog brain.iScience · 2023Article
- Bioelectric networks: the cognitive glue enabling evolutionary scaling from physiology to mind.Animal cognition · 2023Review
- A Novel Perspective on Neuronal Control of Anatomical Patterning, Remodeling, and Maintenance.International journal of molecular sciences · 2023Review
- The salamander blastema within the broader context of metazoan regeneration.Frontiers in cell and developmental biology · 2023Review
- A Computational Approach to Explaining Bioelectrically Induced Persistent, Stochastic Changes of Axial Polarity in Planarian Regeneration.Bioelectricity · 2022Article
- Minimal Developmental Computation: A Causal Network Approach to Understand Morphogenetic Pattern Formation.Entropy (Basel, Switzerland) · 2022Article
- Stability and robustness properties of bioelectric networks: A computational approach.Biophysics reviews · 2021Review
- Animal regeneration in the era of transcriptomics.Cellular and molecular life sciences : CMLS · 2021Review
- Bistability of somatic pattern memories: stochastic outcomes in bioelectric circuits underlying regeneration.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Dynamic Modeling of Transcriptional Gene Regulatory Networks.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Nervous system and tissue polarity dynamically adapt to new morphologies in planaria.Developmental biology · 2020Article
- Emergence of informative higher scales in biological systems: a computational toolkit for optimal prediction and control.Communicative & integrative biology · 2020Article
- Interplay between morphogen-directed positional information systems and physiological signaling.Developmental dynamics : an official publication of the American Association of Anatomists · 2020Review
- Does regeneration recapitulate phylogeny? Planaria as a model of body-axis specification in ancestral eumetazoa.Communicative & integrative biology · 2020Article
- Classification-Based Inference of Dynamical Models of Gene Regulatory Networks.G3 (Bethesda, Md.) · 2019Article
- Hierarchical pattern formation during amphibian limb regeneration.Bio Systems · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Control of axial polarity during regeneration is a crucial open question. We developed a quantitative model of regenerating planaria, which elucidates self-assembly mechanisms of morphogen gradients required for robust body-plan control. The computational model has been developed to predict the fraction of heteromorphoses expected in a population of regenerating planaria fragments subjected to different treatments, and for fragments originating from different regions along the anterior-posterior and medio-lateral axis. This allows for a direct comparison between computational and experimental regeneration outcomes. Vector transport of morphogens was identified as a fundamental requirement to account for virtually scale-free self-assembly of the morphogen gradients observed in planarian homeostasis and regeneration. The model correctly describes altered body-plans following many known experimental manipulations, and accurately predicts outcomes of novel cutting scenarios, which we tested. We show that the vector transport field coincides with the alignment of nerve axons distributed throughout the planarian tissue, and demonstrate that the head-tail axis is controlled by the net polarity of neurons in a regenerating fragment. This model provides a comprehensive framework for mechanistically understanding fundamental aspects of body-plan regulation, and sheds new light on the role of the nervous system in directing growth and form.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.