ArticleACS nano2019
Reconfigurable DNA Origami Nanocapsule for pH-Controlled Encapsulation and Display of Cargo.
Article in ACS nano, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
92 citing papers in PubMed.
- pH-Driven Actuation of Unmodified DNA Origami Rectangles.Angewandte Chemie (International ed. in English) · 2026Article
- Advances in DNA nanostructures for pathogenic microorganisms.Materials today. Bio · 2026Review
- Programmable Functional Silicification of DNA Origami Nanostructures.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Programmable DNA Logic Systems for Applications in Biomedicine.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Review
- Dynamic Covalent Functionalization of DNA Origami via Iminoboronate Chemistry.Journal of the American Chemical Society · 2026Article
- DNA origami-based drug delivery and cell manipulation: toward intelligent nanomedicine.RSC chemical biology · 2026Review
- DNA-Enzyme Hybrid Nanostructures: Functional Materials to Modulate Enzymatic Activity.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Tools For Building Artificial Biological Nanostructures.ACS nano · 2026Review
- Dynamic DNA Nanomachines for Biosensing and Drug Delivery.Sensors (Basel, Switzerland) · 2026Review
- Construction of a COChemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Electronic Actuation of Surface-Immobilized, pH-Responsive DNA Nanoswitches.ACS applied materials & interfaces · 2026Article
- Programmable Nanoscale Motion via Molecular Patterning on DNA Origami.Angewandte Chemie (International ed. in English) · 2026Article
- DNA Nanostructure-Assembled Metallic Nanoparticles for Biosensing Applications.Molecules (Basel, Switzerland) · 2026Review
- Design biology and mind-body health.Journal, genetic engineering & biotechnology · 2025Review
- Single-Molecule DNA Tweezers Enable Programmable Control of Enzyme Activity via Arbitrary Molecular Cues.Angewandte Chemie (International ed. in English) · 2025Article
- Article
- Design and Assembly of a Cargo-Agnostic Hollow Two-Lidded DNA Origami Box.ACS applied bio materials · 2025Article
- Stimuli-Responsive Oligolysine-PEG Coatings for Reductive-Triggered Decomplexation.ACS polymers Au · 2025Article
- Toward high-density streptavidin arrays on DNA origami nanostructures.RSC advances · 2025Article
- Wireframe DNA Origami Capable of Vertex-protruding Transformation.Chembiochem : a European journal of chemical biology · 2025Article
32 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA nanotechnology provides a toolbox for creating custom and precise nanostructures with nanometer-level accuracy. These nano-objects are often static by nature and serve as versatile templates for assembling various molecular components in a user-defined way. In addition to the static structures, the intrinsic programmability of DNA nanostructures allows the design of dynamic devices that can perform predefined tasks when triggered with external stimuli, such as drug delivery vehicles whose cargo display or release can be triggered with a specified physical or chemical cue in the biological environment. Here, we present a DNA origami nanocapsule that can be loaded with cargo and reversibly opened and closed by changing the pH of the surrounding solution. Moreover, the threshold pH value for opening/closing can be rationally designed. We characterize the reversible switching and a rapid opening of "pH-latch"-equipped nanocapsules using Förster resonance energy transfer. Furthermore, we demonstrate the full cycle of capsule loading, encapsulation, and displaying the payload using metal nanoparticles and functional enzymes as cargo mimics at physiologically relevant ion concentrations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.