ArticleeLife2019
Cerebellar folding is initiated by mechanical constraints on a fluid-like layer without a cellular pre-pattern.
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Purkinje cell arrival at the Purkinje cell layer orchestrates cerebellar foliation and its temporal sequence.iScience · 2026Article
- Computational investigation of mechanical mechanisms underlying diverse cerebellar lobular morphologies.Biomechanics and modeling in mechanobiology · 2026Article
- Model recapitulates regenerative limb blastema formation through local softening of the wounded epithelium.bioRxiv : the preprint server for biology · 2026Article
- Fluid shear stress activates a targetable mechano-metastatic cascade to promote medulloblastoma metastasis.Nature biomedical engineering · 2026Article
- Spatiotemporal histogenesis of the developing human cerebellum reveals dynamic layering of Bergmann glia.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Neurodevelopmental origins of structural and psychomotor defects in CXCR4-linked primary immunodeficiency.Neuron · 2025Article
- Enhancing 3-D Radio Frequency Data in Quantitative Acoustic Microscopy Using Quantum-Driven Prior at 250 MHz and 500 MHz.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2025Article
- Attenuation Estimation and Acoustic Characterization of Mouse Lymph Node Tumor Using High-frequency Ultrasound.Molecular imaging and biology · 2025Article
- Altered extracellular matrix structure and elevated stiffness in a brain organoid model for disease.Nature communications · 2025Article
- Prenatal assessment of brain malformations on neuroimaging: an expert panel review.Brain : a journal of neurology · 2024Review
- Mechanical state transitions in the regulation of tissue form and function.Nature reviews. Molecular cell biology · 2024Review
- Cell division angle predicts the level of tissue mechanics that tune the amount of cerebellar folding.Development (Cambridge, England) · 2024Article
- A Quantum Denoising-Based Resolution Enhancement Framework for 250-MHz and 500-MHz Quantitative Acoustic Microscopy.IEEE transactions on computational imaging · 2024Article
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- Cerebellum lineage allocation, morphogenesis and repair: impact of interplay amongst cells.Development (Cambridge, England) · 2022Review
- Appreciating the role of cell shape changes in the mechanobiology of epithelial tissues.Biophysics reviews · 2022Review
- Injury-induced ASCL1 expression orchestrates a transitory cell state required for repair of the neonatal cerebellum.Science advances · 2021Article
- CHARGE syndrome protein CHD7 regulates epigenomic activation of enhancers in granule cell precursors and gyrification of the cerebellum.Nature communications · 2021Article
- Regional changes in the elastic properties of myopic Guinea pig sclera.Experimental eye research · 2019Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Models based in differential expansion of elastic material, axonal constraints, directed growth, or multi-phasic combinations have been proposed to explain brain folding. However, the cellular and physical processes present during folding have not been defined. We used the murine cerebellum to challenge folding models with in vivo data. We show that at folding initiation differential expansion is created by the outer layer of proliferating progenitors expanding faster than the core. However, the stiffness differential, compressive forces, and emergent thickness variations required by elastic material models are not present. We find that folding occurs without an obvious cellular pre-pattern, that the outer layer expansion is uniform and fluid-like, and that the cerebellum is under radial and circumferential constraints. Lastly, we find that a multi-phase model incorporating differential expansion of a fluid outer layer and radial and circumferential constraints approximates the in vivo shape evolution observed during initiation of cerebellar folding.
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