Evidence map›Paper›PMID 30989838›Full record

ArticleJournal of biomedical optics2019

Phantom-based evaluation of near-infrared intracranial hematoma detector performance.

Jianting Wang, Jonathan Lin, Yu Chen, Cristin G Welle, T Joshua Pfefer

Open access · goldAbstract read
In one paragraph

Article in Journal of biomedical optics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Jianting WangU.S. Food and Drug Administration, Center for Devices and Radiological Health, Silver Spring, Maryla, United States.
Jonathan LinU.S. Food and Drug Administration, Center for Devices and Radiological Health, Silver Spring, Maryla, United States.
Yu ChenUniversity of Maryland, Fischell Department of Bioengineering, College Park, Maryland, United States.
Cristin G WelleU.S. Food and Drug Administration, Center for Devices and Radiological Health, Silver Spring, Maryla, United States.
T Joshua PfeferU.S. Food and Drug Administration, Center for Devices and Radiological Health, Silver Spring, Maryla, United States.
Center for Devices and Radiological Health · USUnited States Food and Drug Administration · USUniversity of Maryland, College Park · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Near-infrared spectroscopy (NIRS) is emerging as a rapid, low-cost approach for point-of-care triage of hematomas resulting from traumatic brain injury. However, there remains a lack of standardized test methods for benchtop performance assessment of these devices and incomplete understanding of relevant light-tissue interactions. We propose a phantom-based test method for systems operating near the 800-nm oxy-/deoxy-hemoglobin isosbestic point and implement it to evaluate a clinical system. Semi-idealized phantom geometries are designed to represent epidural/subdural, subarachnoid, and intracerebral hemorrhages. Measurements of these phantoms are made with a commercial NIRS-based hematoma detector to quantify the effect of hematoma type, depth, and size, as well as measurement repeatability and detector positioning relative to the hematoma. Results indicated high sensitivity to epidural/subdural and subarachnoid hematomas. Intracerebral hematomas are detectable to a maximum depth of ∼2.5  cm, depending on thickness and diameter. The maximum lateral detection area for the single-emitter/single-collector device studied here appears elliptical and decreases strongly with inclusion depth. Overall, this study provides unique insights into hematoma detector function and indicates the utility of modular polymer tissue phantoms in performance tests for emerging NIRS-based cerebral diagnostic technology.

Indexed as

Phantoms, ImagingSpectroscopy, Near-InfraredHematomaHumansReproducibility of Resultshematoma detectionlight–tissue interactionnear-infrared spectroscopystandardizationtissue phantomstraumatic brain injury

Identifiers

PMID30989838
PMCPMC6989771
OpenAlexW2939838557

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.