ArticleAnatomical record (Hoboken, N.J. : 2007)2019
Anatomical Assessment of the Adult Skeleton of Zebrafish Reared Under Different Thyroid Hormone Profiles.
Article in Anatomical record (Hoboken, N.J. : 2007), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 52 citations in OpenAlex.
- Chronic Perfluorooctanoic Acid Exposure in Young Adult Zebrafish Affects Scale and Internal Skeleton Bone Metabolism, as Well as Offspring Bone Development.International journal of molecular sciences · 2026Article
- foxe1 mutant zebrafish show indications of a hypothyroid phenotype and increased sensitivity to ethanol for craniofacial malformations.Developmental dynamics : an official publication of the American Association of Anatomists · 2025Article
- The overlooked first intercostal ligament: Does it help to stabilize the Weberian apparatus?Journal of anatomy · 2025Article
- Experimentally Manipulating the Thyroid Hormone Axis in Zebrafish.Methods in molecular biology (Clifton, N.J.) · 2025Review
- Phylogenomic analysis of the Lake Kronotskoe species flock of Dolly Varden charr reveals genetic and developmental signatures of sympatric radiation.Development (Cambridge, England) · 2024Article
- The Impact of Polychlorinated Biphenyls on the Development of Zebrafish (Biomedicines · 2024Article
- The transcriptional landscape underlying larval development and metamorphosis in the Malabar grouper (eLife · 2024Article
- Phylogenomic analysis of the Lake Kronotskoe species flock of Dolly Varden charr reveals genetic and developmental signatures of sympatric radiation.bioRxiv : the preprint server for biology · 2024Article
- Finite element modelling of sound transmission in the Weberian apparatus of zebrafish (Journal of the Royal Society, Interface · 2024Article
- Thyroid hormone regulates proximodistal patterning in fin rays.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Thyroid hormone shapes craniofacial bones during postembryonic zebrafish development.Evolution & development · 2022Article
- Zebrafish as an experimental model for the simulation of neurological and craniofacial disorders.Veterinary world · 2022Review
- Zebrafish endochondral growth zones as they relate to human bone size, shape and disease.Frontiers in endocrinology · 2022Review
- The Evolution of Feeding Mechanics in the Danioninae, or Why Giant Danios Don't Suck Like Zebrafish.Integrative organismal biology (Oxford, England) · 2022Article
- Heads and tails: The notochord develops differently in the cranium and caudal fin of Atlantic Salmon (Salmo salar, L.).Anatomical record (Hoboken, N.J. : 2007) · 2021Article
- Thyroid hormone deficiency during zebrafish development impairs central nervous system myelination.PloS one · 2021Article
- Role of thyroid hormones in craniofacial development.Nature reviews. Endocrinology · 2020Review
- The Role of the Thyroid Axis in Fish.Frontiers in endocrinology · 2020Review
- Thyroid hormone coordinates developmental trajectories but does not underlie developmental truncation in danionins.Developmental dynamics : an official publication of the American Association of Anatomists · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Thyroid hormone (TH) directs the growth and maintenance of tissues throughout the body during development and into adulthood, and plays a particularly important role in proper ossification and homeostasis of the skeleton. To better understand the roles of TH in the skeletogenesis of a vertebrate model, and to define areas of the skeleton that are particularly sensitive to developmental TH, we examined the effects of hypo- and hyperthyroidism on skeletal development in zebrafish. Performing a bone-by-bone anatomical assessment on the entire skeleton of adult fish, we found that TH is required for proper ossification, growth, morphogenesis, and fusion of numerous bones. We showed that the pectoral girdle, dermatocranium, Weberian apparatus, and dentary are particularly sensitive to TH, and that TH affects development of skeletal element regardless of bone type and developmental origin. Indeed, the hormone does not universally promote ossification: we found that developmental TH prevents ectopic ossification in multiple thin bones and within connective tissue of the jaw. In all, we found that TH regulates proper morphogenesis and ossification in the majority of zebrafish bones, and that the requirement for the hormone extends across bone types and developmental profiles. Anat Rec, 302:1754-1769, 2019. © 2019 American Association for Anatomy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.