Evidence map›Paper›PMID 30989612›Full record

ArticleCell stress & chaperones2019

Intracellular catalase activity instead of glutathione level dominates the resistance of cells to reactive oxygen species.

Meng-Xin Zhao, Jun-Lin Wen, Lu Wang, Xiao-Ping Wang, Tong-Sheng Chen

Open access · greenAbstract read
In one paragraph

Article in Cell stress & chaperones, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 73 citations in OpenAlex.

  1. ACS nanoscience Au · 2026
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  7. Article
  8. Discovery of novel AMolecular diversity · 2025
    Article
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  11. [Vitexin-4 ″-Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2025
    Article
  12. Article
  13. Article
  14. Oxidative Stress in Cardiovascular Diseases: Mechanisms and Exploring Advanced Therapies.Cardiovascular & hematological agents in medicinal chemistry · 2025
    Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Meng-Xin ZhaoDepartment of Pain Management, the First Affiliated Hospital, Jinan University, Guangzhou, 510632, China.
Jun-Lin WenDepartment of Pain Management, the First Affiliated Hospital, Jinan University, Guangzhou, 510632, China.
Lu WangMOE Key Laboratory of Laser Life Science & College of Life Science, South China Normal University, Guangzhou, 510631, China.
Xiao-Ping WangDepartment of Pain Management, the First Affiliated Hospital, Jinan University, Guangzhou, 510632, China. txp2938@jnu.edu.cn.
Tong-Sheng ChenMOE Key Laboratory of Laser Life Science & College of Life Science, South China Normal University, Guangzhou, 510631, China.
First Affiliated Hospital of Jinan University · CNSouth China Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Artesunate (ARS) induced significant reactive oxygen species (ROS) generation in HepG2, HeLa, and A549 lines. However, ARS induced ROS-dependent apoptosis in HeLa and A549 cell lines but ROS-independent apoptosis in HepG2 cells. A total of 200 μM hydrogen peroxide (H

Indexed as

A549 CellsApoptosisArtesunateCatalaseCell SurvivalGlutathioneHeLa CellsHep G2 CellsHumansHydrogen PeroxideOxidative StressReactive Oxygen SpeciesArtesunateCatalaseCAT protein, humanGlutathioneHydrogen PeroxideReactive Oxygen SpeciesCatalaseGlutathioneHydrogen peroxideReactive oxygen speciesResistance

Identifiers

PMID30989612
PMCPMC6527626
OpenAlexW2940052832

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.