Evidence map›Paper›PMID 30989598›Full record

ArticleEnvironmental science and pollution research international2019

Predicting the cytotoxicity of disinfection by-products to Chinese hamster ovary by using linear quantitative structure-activity relationship models.

Li-Tang Qin, Xin Zhang, Yu-Han Chen, Ling-Yun Mo, Hong-Hu Zeng, Yan-Peng Liang, Hua Lin, Dun-Qiu Wang

Abstract read
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In one paragraph

Article in Environmental science and pollution research international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Li-Tang QinCollege of Environmental Science and Engineering, Guilin University of Technology, Guilin, 541004, China.
Xin ZhangCollege of Environmental Science and Engineering, Guilin University of Technology, Guilin, 541004, China.
Yu-Han ChenCollege of Environmental Science and Engineering, Guilin University of Technology, Guilin, 541004, China.
Ling-Yun MoCollege of Environmental Science and Engineering, Guilin University of Technology, Guilin, 541004, China. molingyun123@126.com.
Hong-Hu ZengCollege of Environmental Science and Engineering, Guilin University of Technology, Guilin, 541004, China.
Yan-Peng LiangCollege of Environmental Science and Engineering, Guilin University of Technology, Guilin, 541004, China.
Hua LinCollege of Environmental Science and Engineering, Guilin University of Technology, Guilin, 541004, China. linhua5894@163.com.
Dun-Qiu WangCollege of Environmental Science and Engineering, Guilin University of Technology, Guilin, 541004, China.

Funding

Guangxi Science and Technology Planning Project GuiKe-AD18126018National Natural Science Foundation of China 21667013National Natural Science Foundation of China 21866010National Natural Science Foundation of China 51638006Natural Science Foundation of Guangxi 2017GXNSFAA198346
6 · The paper itself

Abstract

A suitable model to predict the toxicity of current and continuously emerging disinfection by-products (DBPs) is needed. This study aims to establish a reliable model for predicting the cytotoxicity of DBPs to Chinese hamster ovary (CHO) cells. We collected the CHO cytotoxicity data of 74 DBPs as the endpoint to build linear quantitative structure-activity relationship (QSAR) models. The linear models were developed by using multiple linear regression (MLR). The MLR models showed high performance in both internal (leave-one-out cross-validation, leave-many-out cross-validation, and bootstrapping) and external validation, indicating their satisfactory goodness of fit (R

Indexed as

AnimalsCell SurvivalCHO CellsCricetinaeCricetulusDisinfectantsDisinfectionLethal Dose 50Linear ModelsMultivariate AnalysisQuantitative Structure-Activity RelationshipWater Pollutants, ChemicalDisinfectantsWater Pollutants, ChemicalChinese hamster ovaryCytotoxicityDisinfection by-productsQuantitative structure-activity relationship

Identifiers

PMID30989598

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.