Evidence map›Paper›PMID 30989577›Full record

ArticleMedical & biological engineering & computing2019

Effect of carotid image-based phenotypes on cardiovascular risk calculator: AECRS1.0.

Narendra N Khanna, Ankush D Jamthikar, Deep Gupta, Tadashi Araki, Matteo Piga, Luca Saba, Carlo Carcassi, Andrew Nicolaides, John R Laird, Harman S Suri and 6 more

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In one paragraph

Article in Medical & biological engineering & computing, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 11 institutions in 7 countries.

Narendra N KhannaDepartment of Cardiology, Indraprastha Apollo Hospitals, New Delhi, India.
Ankush D JamthikarDepartment of ECE, Visvesvaraya National Institute of Technology, Nagpur, Maharashtra, India.
Deep GuptaDepartment of ECE, Visvesvaraya National Institute of Technology, Nagpur, Maharashtra, India.
Tadashi ArakiDivision of Cardiovascular Medicine, Toho University, Tokyo, Japan.
Matteo PigaDepartment of Rheumatology, University of Cagliari, Cagliari, Italy.
Luca SabaDepartment of Radiology, University of Cagliari, Cagliari, Italy.
Carlo CarcassiDepartment of Genetics, University of Cagliari, Cagliari, Italy.
Andrew NicolaidesVascular Diagnostic Center, University of Cyprus, Nicosia, Cyprus.
John R LairdHeart and Vascular Institute, Adventist Health St. Helena, St. Helena, CA, USA.
Harman S SuriBrown University, Providence, RI, USA.
Ajay GuptaDepartment of Radiology, Cornell Medical Center, New York, NY, USA.
Sophie MavrogeniCardiology Clinic, Onassis Cardiac Surgery Center, Athens, Greece.
Athanasios ProtogerouDepartment of Cardiovascular Prevention & Research Unit Clinic & Laboratory of Pathophysiology, National and Kapodistrian University of Athens, Athens, Greece.
Petros SfikakisRheumatology Unit, National Kapodistrian University of Athens, Athens, Greece.
George D KitasResearch & Development-Academic Affairs, Dudley Group NHS Foundation Trust, Dudley, UK.
Jasjit S SuriStroke Monitoring and Diagnostic Division, AtheroPoint™, 208 Otter Glen CT, Roseville, CA, 95661, USA. Jasjit.Suri@atheropoint.com.
University of Cagliari · ITNational and Kapodistrian University of Athens · GRVisvesvaraya National Institute of Technology · INBrown University · USCornell University · USDudley Group NHS Foundation Trust · GBIndraprastha Apollo Hospitals · INOnassis Cardiac Surgery Center · GRSt. Helena Hospital · USToho University · JPUniversity of Cyprus · CY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Today, the 10-year cardiovascular risk largely relies on conventional cardiovascular risk factors (CCVRFs) and suffers from the effect of atherosclerotic wall changes. In this study, we present a novel risk calculator AtheroEdge Composite Risk Score (AECRS1.0), designed by fusing CCVRF with ultrasound image-based phenotypes. Ten-year risk was computed using the Framingham Risk Score (FRS), United Kingdom Prospective Diabetes Study 56 (UKPDS56), UKPDS60, Reynolds Risk Score (RRS), and pooled composite risk (PCR) score. AECRS1.0 was computed by measuring the 10-year five carotid phenotypes such as IMT (ave., max., min.), IMT variability, and total plaque area (TPA) by fusing eight CCVRFs and then compositing them. AECRS1.0 was then benchmarked against the five conventional cardiovascular risk calculators by computing the receiver operating characteristics (ROC) and area under curve (AUC) values with a 95% CI. Two hundred four IRB-approved Japanese patients' left/right common carotid arteries (407 ultrasound scans) were collected with a mean age of 69 ± 11 years. The calculators gave the following AUC: FRS, 0.615; UKPDS56, 0.576; UKPDS60, 0.580; RRS, 0.590; PCRS, 0.613; and AECRS1.0, 0.990. When fusing CCVRF, TPA reported the highest AUC of 0.81. The patients were risk-stratified into low, moderate, and high risk using the standardized thresholds. The AECRS1.0 demonstrated the best performance on a Japanese diabetes cohort when compared with five conventional calculators. Graphical abstract AECRS1.0: Carotid ultrasound image phenotype-based 10-year cardiovascular risk calculator. The figure provides brief overview of the proposed carotid image phenotype-based 10-year cardiovascular risk calculator called AECRS1.0. AECRS1.0 was also benchmarked against five conventional cardiovascular risk calculators (Framingham Risk Score (FRS), United Kingdom Prospective Diabetes Study 56 (UKPDS56), UKPDS60, Reynolds Risk Score (RRS), and pooled composite risk (PCR) score).

Indexed as

AgedAged, 80 and overAsian PeopleCardiovascular DiseasesCarotid ArteriesCarotid Intima-Media ThicknessCarotid StenosisFemaleHumansImage Processing, Computer-AssistedMaleMiddle AgedRisk FactorsROC CurveUltrasonography10-year risk predictionAtherosclerosisCarotid intima-media thicknessComposite risk scoreConventional cardiovascular riskStrokeUltrasound

Identifiers

PMID30989577
OpenAlexW2940017569

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.