ArticleEndocrine2019
Network-based transcriptomic analysis reveals novel melatonin-sensitive genes in cardiovascular system.
Article in Endocrine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 9 citations in OpenAlex.
- RNA-Interference-Mediated miR-122-Based Gene Regulation in Colon Cancer, a Structural In Silico Analysis.International journal of molecular sciences · 2022Article
- The Prospective Application of Melatonin in Treating Epigenetic Dysfunctional Diseases.Frontiers in pharmacology · 2022Review
- Weighted Gene Coexpression Network Analysis Reveals Essential Genes and Pathways in Bipolar Disorder.Frontiers in psychiatry · 2021Article
- Generation of metabolically functional hepatocyte-like cells from dedifferentiated fat cells by Foxa2, Hnf4a and Sall1 transduction.Genes to cells : devoted to molecular & cellular mechanisms · 2020Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeHeart disease is a major cause of mortality and disability worldwide. Melatonin is a neuroendocrine hormone and has been found to be protective in heart disease. However, the molecular basis underlying this cardioprotective effect is not fully understood. Here we aim to investigate melatonin-sensitive genes in cardiovascular system using public gene expression databases.
methodsAn innovative genomic analysis method, the weighted gene co-expression network analysis (WGCNA) combined with differential gene expression analysis, was used in this study. The algorithm was implemented in R/Bioconductor.
resultsUsing this method, we provide a comprehensive characterization of transcriptional profiles associated with melatonin treatment. We found that 357 differentially expressed genes (DEGs) were highly sensitive to melatonin in mouse myocardium. Enrichment analysis showed that these 357 genes were mostly related to GO:0051984 (positive regulation of chromosome segregation), GO:0016605 (PML body) and GO:0006281 (DNA repair). We further obtained 5 hub genes from the 357 DEGs, including Set, Dhx40, Scaf11, Cfh, and Nup43.
conclusionsWe identified numerous melatonin-sensitive genes and further identified five hub genes. The five novel genes are possibly associated with the myocardial benefits of melatonin.
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Registered trials
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