Evidence map›Paper›PMID 30989439›Full record

ArticleMolecular imaging and biology2019

Retrospective Brain Motion Correction in Glutamate Chemical Exchange Saturation Transfer (GluCEST) MRI.

Dong-Hoon Lee, Do-Wan Lee, Jae-Im Kwon, Chul-Woong Woo, Sang-Tae Kim, Jeong Kon Kim, Kyung Won Kim, Dong-Cheol Woo

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Article in Molecular imaging and biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Dong-Hoon LeeFaculty of Health Sciences and Brain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0002-5013-4440
Do-Wan LeeCenter for Bioimaging of New Drug Development, Asan Medical Center, Asan Institute for Life Sciences, Seoul, Republic of Korea.
Jae-Im KwonMR Core Laboratory, Convergence Medicine Research Center, Asan Medical Center, Asan Institute for Life Sciences, Seoul, Republic of Korea.
Chul-Woong WooMR Core Laboratory, Convergence Medicine Research Center, Asan Medical Center, Asan Institute for Life Sciences, Seoul, Republic of Korea.
Sang-Tae KimMR Core Laboratory, Convergence Medicine Research Center, Asan Medical Center, Asan Institute for Life Sciences, Seoul, Republic of Korea.
Jeong Kon KimDepartment of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Kyung Won KimDepartment of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Dong-Cheol WooMR Core Laboratory, Convergence Medicine Research Center, Asan Medical Center, Asan Institute for Life Sciences, Seoul, Republic of Korea. dcwoo@amc.seoul.kr.
Asan Medical Center · KRUlsan College · KRThe University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the feasibility of motion correction in glutamate chemical exchange saturation transfer (GluCEST) imaging, using a rat model of epileptic seizure. PROCEDURES: Epileptic seizure was induced in six male Wistar rats by intraperitoneal injection of kainic acid (KA). CEST data were obtained using a 7.0 T Bruker MRI scanner before and 3 h after KA injection. Retrospective motion correction was performed in CEST images using a gradient-based motion correction (GradMC) algorithm. GluCEST signals in the hippocampal regions were quantitatively evaluated with and without motion correction.

resultsCalculated GluCEST signals differed significantly between the pre-KA injection group, regardless of motion-correction implementation, and the post-KA injection group with motion correction (3.662 ± 1.393 % / 3.726 ± 1.982 % for pre-KA injection group with/without motion correction vs. 6.996 ± 1.684 % for post-KA injection group with motion correction; all P < 0.05).

conclusionsOur results clearly show that GradMC can be used in CEST imaging for efficient correction of seizure-like motion. The GradMC can be further implemented in various CEST imaging techniques to increase the accuracy of analysis.

Indexed as

Magnetic Resonance ImagingMotionAnimalsBrainBrain MappingGlutamic AcidImage Processing, Computer-AssistedKainic AcidMaleRats, WistarRetrospective StudiesGlutamic AcidKainic AcidChemical exchange saturation transferGlutamateGradient-based motion correctionRetrospective motion correction

Identifiers

PMID30989439
OpenAlexW2937750580

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.