Evidence map›Paper›PMID 30989378›Full record

SynthesisActa diabetologica2019

Systematic review: associations of calcium intake, vitamin D intake, and physical activity with skeletal outcomes in people with Type 1 diabetes mellitus.

María Cristina Gil-Díaz, Jennifer Raynor, Kimberly O O'Brien, George J Schwartz, David R Weber

Open access · greenAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Acta diabetologica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Impact of Diabetes Mellitus on Bone Health.International journal of molecular sciences · 2019
    Review
  13. Type 1 Diabetes and Bone Fragility: Links and Risks.Diabetes, metabolic syndrome and obesity : targets and therapy · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

María Cristina Gil-DíazGolisano Children's Hospital, University of Rochester, 601 Elwood Ave, Box 690, Rochester, NY, 14642, USA.ORCID http://orcid.org/0000-0002-4580-3240
Jennifer RaynorEdward G. Miner Library, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY, 14642, USA.
Kimberly O O'BrienCollege of Human Ecology, Cornell University, 230 Savage Hall, Ithaca, NY, 14850, USA.ORCID http://orcid.org/0000-0002-0954-1706
George J SchwartzGolisano Children's Hospital, University of Rochester, 601 Elwood Ave, Box 690, Rochester, NY, 14642, USA.
David R WeberGolisano Children's Hospital, University of Rochester, 601 Elwood Ave, Box 690, Rochester, NY, 14642, USA. David_weber@urmc.rochester.edu.ORCID http://orcid.org/0000-0001-6895-2372
Golisano Children's Hospital · USCornell University · USUniversity of Rochester Medical Center · US

Funding

Investigation of Hypercalciuria as a Cause of Impaired Bone Mineral Accrual in Type 1 DiabetesK23DK114477 · NIDDK · UNIVERSITY OF ROCHESTER · PI WEBER, DAVID R · 2017 to 2019
$573k
NIDDK NIH HHS K23 DK114477
6 · The paper itself

Abstract

aimsThe skeletal complications of type 1 diabetes (T1D) include low bone density, poor bone quality and fractures. Greater calcium intake, vitamin D intake, and physical activity are commonly recommended to improve bone health in patients with T1D. However, it is not clear whether these factors are affected by T1D or improve clinical outcomes.

methodsThe objective of this study was to systematically review the literature for evidence of associations between calcium intake, vitamin D intake, and physical activity and skeletal outcomes in T1D. In accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, twenty-two studies were included in this review.

resultsThe prevalence of calcium deficiency was high and encompassed greater than 50% of participants in the majority of studies. Despite this finding, there was no clear association between calcium intake and bone density in any study. Calcitriol use was associated with gains in bone density in one study but was not associated with changes in bone turnover markers in a second report. No studies specifically investigated the impact of vitamin D2 or D3 supplementation on bone health. Two studies reported a beneficial effect of physical activity interventions on bone accrual in children. The findings from observational studies of physical activity were mixed.

conclusionThere are insufficient data to determine if deficient calcium intake, vitamin D intake, or physical activity contributes to the skeletal complications of T1D. Future studies specifically designed to assess the impact of these interventions on the skeleton in T1D participants are needed.

Indexed as

AdolescentAdultAgedBone and BonesBone DensityCalciumChildDiabetes ComplicationsDiabetes Mellitus, Type 1EatingExerciseFemaleFractures, BoneHumansMaleMiddle AgedCalciumVitamin DBone densityCalciumExercisePhysical activityType 1 diabetesVitamin D

Identifiers

PMID30989378
PMCPMC6751023
OpenAlexW2938702933

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.