Evidence map›Paper›PMID 30989323›Full record

ArticleInternational journal of legal medicine2019

Forensic performance of 30 InDels included in the Investigator DIPplex system in Miao population and comprehensive genetic relationship in China.

Pengyu Chen, Li Luo, Hongyan Gao, Jian Wu, Yudan Wang, Guanglin He, Yanyan Han

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Article in International journal of legal medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

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4citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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4 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Pengyu ChenCenter of Forensic Expertise, Affiliated hospital of Zunyi Medical University, Zunyi, 563099, Guizhou, China.
Li LuoCenter of Forensic Expertise, Affiliated hospital of Zunyi Medical University, Zunyi, 563099, Guizhou, China.
Hongyan GaoCenter of Forensic Expertise, Affiliated hospital of Zunyi Medical University, Zunyi, 563099, Guizhou, China.
Jian WuCenter of Forensic Expertise, Affiliated hospital of Zunyi Medical University, Zunyi, 563099, Guizhou, China.
Yudan WangCenter of Forensic Expertise, Affiliated hospital of Zunyi Medical University, Zunyi, 563099, Guizhou, China.
Guanglin HeInstitute of Forensic Medicine, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, 610041, Sichuan, China. Guanglinhescu@163.com.
Yanyan HanSchool of Public Health, Zunyi Medical University, Zunyi, 563099, Guizhou, China. hanyanyan1984@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Binary markers of insertion and deletion (InDel) play an important role in forensic personal identification, parentage testing, and individual ancestry inference. We first genotyped 30 InDels included in the Investigator DIPplex in 403 unrelated healthy Zunyi Miao people and analyzed the genetic polymorphisms, as well as explored the genetic relationship between Miao and 32 Chinese reference populations. No departures from the HWE were observed. The combined power of discrimination and the combined probability of exclusion were 0.99999999998 and 0.9884, respectively. Forensic parameters demonstrated that 30 markers are polymorphic and informative in the Zunyi Miao population and can be used as a tool for forensic personal identification and parentage testing. Allele frequency divergence analysis found that 12 out of 30 displaying high allele frequency difference between Turkic-speaking populations and other Chinese populations can be used as candidates of ancestry informative markers for ancestry inference of sub-population in East Asia. Population genetic parameters in the comprehensive population comparison among 33 Chinese populations indicated that our studied Hmong-Mien-speaking Miao has a close genetic relationship with geographically adjacent Enshi Tujia and genetically differentiate from Turkic-speaking populations.

Indexed as

INDEL MutationPolymorphism, GeneticSequence Analysis, DNAAsian PeopleChinaFemaleForensic GeneticsGene FrequencyGenetics, PopulationGenotypeHumansMaleProbabilityForensic geneticsInDelsIndividual identificationMiaoParentage testing

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.