ArticleAnalytical and bioanalytical chemistry2019
Standardization procedures for real-time breath analysis by secondary electrospray ionization high-resolution mass spectrometry.
Article in Analytical and bioanalytical chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 90 citations in OpenAlex.
- Exhaled volatile organic compounds analysis in clinical pediatrics: a systematic review.Pediatric research · 2021Pooled it
- Non-Invasive Estimation of Systemic Drug Exposure Using Exhaled Breath Metabolomics in Humans: A Translational Proof-of-Concept Study.Clinical pharmacology and therapeutics · 2026Article
- Cold induced pain elicits reproducible breath metabolomic responses across geographically distinct populations.iScience · 2026Article
- Evaluating the VOCORDER device for early disease detection through breath analysis: study protocol for a two-phase clinical study.BMJ open · 2026Article
- Real-time breath metabolomics as catalyst for personalized lung cancer diagnostics: prospective matched case-control trial (LUCAbreath).Translational lung cancer research · 2026Article
- Metabolic effects following initiation of single-inhaler triple therapy in COPD: a prospective observational study.Molecular medicine (Cambridge, Mass.) · 2026Observational
- Acute COPD exacerbation despite triple inhaled therapy: a molecular insight - TripleEx study.Respiratory research · 2025Observational
- Mid-infrared acetone gas sensors using substrate-integrated hollow waveguides augmented by advanced preconcentrators.Scientific reports · 2025Article
- Exploring breath metabolomics as a non-invasive tool for detecting pulmonary vascular disease.European heart journal open · 2025Article
- Rapid detection of Tulipalin A with SESI-Orbitrap MS: an exploration across spring flowers.Plant methods · 2025Article
- Article
- Sensitive determination of volatile nitrosamines with ambient pressure ammonium-adduct ionization mass spectrometry.Analytical and bioanalytical chemistry · 2024Article
- Modern approaches for detection of volatile organic compounds in metabolic studies focusing on pathogenic bacteria: Current state of the art.Journal of pharmaceutical analysis · 2024Review
- Article
- Non-invasive monitoring of microbiota and host metabolism using secondary electrospray ionization-mass spectrometry.Cell reports methods · 2023Article
- Article
- Effects of a Volatile Organic Compound Filter on Breath Profiles Measured by Secondary Electrospray High-Resolution Mass Spectrometry.Molecules (Basel, Switzerland) · 2022Article
- Application of Secondary Electrospray Ionization Coupled with High-Resolution Mass Spectrometry in Chemical Characterization of Thermally Generated Aerosols.Journal of the American Society for Mass Spectrometry · 2022Article
- Identification of Exhaled Metabolites in Children with Cystic Fibrosis.Metabolites · 2022Article
- MetHoS: a platform for large-scale processing, storage and analysis of metabolomics data.BMC bioinformatics · 2022Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
Despite the attractiveness of breath analysis as a non-invasive means to retrieve relevant metabolic information, its introduction into routine clinical practice remains a challenge. Among all the different analytical techniques available to interrogate exhaled breath, secondary electrospray ionization high-resolution mass spectrometry (SESI-HRMS) offers a number of advantages (e.g., real-time, yet wide, metabolome coverage) that makes it ideal for untargeted and targeted studies. However, so far, SESI-HRMS has relied mostly on lab-built prototypes, making it difficult to standardize breath sampling and subsequent analysis, hence preventing further developments such as multi-center clinical studies. To address this issue, we present here a number of new developments. In particular, we have characterized a new SESI interface featuring real-time readout of critical exhalation parameters such as CO
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.