Evidence map›Paper›PMID 30989148›Full record

ArticleJournal of veterinary research2019

Pituitary-testicular Axis Dysfunction in Methimazole-induced Hypothyroidism in Rats.

Marcin Gołyński, Michał Metyk, Piotr Szkodziak, Krzysztof Lutnicki, Grzegorz Kalisz, Marcin Szczepanik, Piotr Wilkołek, Piotr Dobrowolski

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of veterinary research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Marcin GołyńskiDepartment and Clinic of Animal Internal Diseases, Faculty of Veterinary Medicine, University of Life Sciences, 20-612 Lublin, Poland.
Michał MetykDepartment and Clinic of Animal Internal Diseases, Faculty of Veterinary Medicine, University of Life Sciences, 20-612 Lublin, Poland.
Piotr Szkodziak3rd Chair and Department of Gynecology, Medical University of Lublin, 20-954 Lublin, Poland.
Krzysztof LutnickiDepartment and Clinic of Animal Internal Diseases, Faculty of Veterinary Medicine, University of Life Sciences, 20-612 Lublin, Poland.
Grzegorz KaliszDepartment of Biopharmacy, Chair of Chemistry, Faculty of Pharmacy with Medical Analytics Division, Medical University of Lublin, 20-093 Lublin, Poland.
Marcin SzczepanikDepartment and Clinic of Animal Internal Diseases, Faculty of Veterinary Medicine, University of Life Sciences, 20-612 Lublin, Poland.
Piotr WilkołekDepartment and Clinic of Animal Internal Diseases, Faculty of Veterinary Medicine, University of Life Sciences, 20-612 Lublin, Poland.
Piotr DobrowolskiDepartment of Comparative Anatomy and Anthropology, Maria Curie-Skłodowska University, 20-033 Lublin, Poland.
University of Life Sciences in Lublin · PLMedical University of Lublin · PLMaria Curie-Skłodowska University · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThyroid hormones play a major role in the regulation of testicular maturation and growth and in the control of Sertoli and Leydig cell functions in adulthood. When naturally occurring, hypothyroidism causes male hypogonadotropic hypogonadism and Sertoli cell function disorders, but when iatrogenic and methimazole-induced its influence on the pituitary-testicular axis function with respect to Sertoli cells is poorly known. MATERIAL AND

methodsMale adult Wistar rats (n = 14) were divided into two groups: E - taking methimazole orally for 60 days, and C - control animals. After 60 d, the concentrations in serum of testosterone, follicle-stimulating and luteinising hormones, and inhibins A and B were measured. Testicles were examined morphologically: the apoptotic Sertoli cell percentage (ASC%) and number of these cells functional per tubular mm

resultsIn group E, inhibin A was higher while inhibin B was lower than in group C. ASC% was higher and FSCN/Tmm

conclusionA specific modulation of Sertoli cell function in the course of methimazole-induced hypothyroidism leads to a simultaneous concentration increase in inhibin A and decrease in B. Inhibin A might share responsibility for pituitary-testicular axis dysfunction and hypogonadotropic hypogonadism in this model of hypothyroidism.

Indexed as

hypogonadisminhibinsratssex hormonesthionaminesthyroid gland

Identifiers

PMID30989148
PMCPMC6458557
OpenAlexW2927906803

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.