ArticleScience advances2019
Contribution of biomimetic collagen-ligand interaction to intrafibrillar mineralization.
Article in Science advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 119 citations in OpenAlex.
- Immune-epigenetic convergence in biomaterial-guided tissue regeneration.Materials today. Bio · 2026Article
- Bone-like Collagen Matrices Through Rapid Intrafibrillar Mineralisation.Journal of functional biomaterials · 2026Article
- Cross-linking of collagen fibrils leads to preferential gap zone mineralization in vitro.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- A novel PCL fiber membrane with a gradient structure for guided bone regeneration.RSC advances · 2026Article
- Cationic hydrogel with sustained lubrication and anti-calcification for osteoarthritis therapy.Journal of nanobiotechnology · 2026Article
- Recent advances in biomaterials for bone regeneration: Bridging innovation and clinical translation.Materials today. Bio · 2026Review
- Endogenous Osteocyte-Osteoclast Signaling Enables Growth Factor-Free Bone Remodeling, Drug Response, and Cancer Invasion in a Nanoscale Calcified Bone-on-a-Chip Model.bioRxiv : the preprint server for biology · 2025Article
- Review
- Polyaspartic Acid-Calcium-Lanthanum Complexes Induce Antibacterial Remineralization of Dentin and In-Depth Occlusion of Dentinal Tubules.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Nanocrystal Compressive Residual Stresses: A Strategy to Strengthen the Bony Spines of Osteocytic and Anosteocytic Fish.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Regulatory potency of oligomeric proanthocyanidins (PACs) on extrafibrillar and intrafibrillar collagen mineralization.Journal of applied polymer science · 2025Article
- Mesoscale orchestration of collagen-based hierarchical mineralization.Nature communications · 2025Article
- Unraveling Nanomaterials in Biomimetic Mineralization of Dental Hard Tissue: Focusing on Advantages, Mechanisms, and Prospects.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Decoding the diabetic bone paradox: How AGEs sabotage skeletal integrity.Cell reports. Medicine · 2024Article
- Advanced glycation end products mediate biomineralization disorder in diabetic bone disease.Cell reports. Medicine · 2024Article
- Exploring the Fibrous Nature of Single-Stranded DNA-Collagen Complexes: Nanostructural Observations and Physicochemical Insights.ACS omega · 2024Article
- Osteoinductive micro-nano guided bone regeneration membrane for in situ bone defect repair.Stem cell research & therapy · 2024Article
- Remineralization of Dentin with Cerium Oxide and Its Potential Use for Root Canal Disinfection.International journal of nanomedicine · 2024Article
- Triggered metabolism of adenosine triphosphate as an explanation for the chemical heterogeneity of heterotopic ossification.Communications chemistry · 2023Article
- An engineered lamellar bone mimicking full-scale hierarchical architecture for bone regeneration.Bioactive materials · 2023Article
Corrections and comments
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Authors and funding
16 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Contemporary models of intrafibrillar mineralization mechanisms are established using collagen fibrils as templates without considering the contribution from collagen-bound apatite nucleation inhibitors. However, collagen matrices destined for mineralization in vertebrates contain bound matrix proteins for intrafibrillar mineralization. Negatively charged, high-molecular weight polycarboxylic acid is cross-linked to reconstituted collagen to create a model for examining the contribution of collagen-ligand interaction to intrafibrillar mineralization. Cryogenic electron microscopy and molecular dynamics simulation show that, after cross-linking to collagen, the bound polyelectrolyte caches prenucleation cluster singlets into chain-like aggregates along the fibrillar surface to increase the pool of mineralization precursors available for intrafibrillar mineralization. Higher-quality mineralized scaffolds with better biomechanical properties are achieved compared with mineralization of unmodified scaffolds in polyelectrolyte-stabilized mineralization solution. Collagen-ligand interaction provides insights on the genesis of heterogeneously mineralized tissues and the potential causes of ectopic calcification in nonmineralized body tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.