ArticleTissue engineering and regenerative medicine2019
Efficient Production of Murine Uterine Damage Model.
Article in Tissue engineering and regenerative medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Comparative Analysis of Vehicles for the Regeneration of Mouse Endometrial Damage Model.Tissue engineering and regenerative medicine · 2026Article
- GM-CSF improves the receptivity of thin endometrium by promoting glandular and stromal cell proliferation in mice and humans.Cell death discovery · 2025Article
- Therapeutic Potential of Menstrual Blood-derived Stem Cells in Attenuating Uterine Adhesion: Novel Strategies and Future Prospect.Current pharmaceutical design · 2025Review
- Thermosensitive hydrogel as a sustained release carrier for mesenchymal stem cell-derived extracellular vesicles in the treatment of intrauterine adhesion.Journal of nanobiotechnology · 2024Article
- Article
- Human umbilical cord platelet-rich plasma to treat endometrial pathologies: methodology, composition and pre-clinical models.Human reproduction open · 2023Article
- Tumor necrosis factor-α-primed mesenchymal stem cell-derived exosomes promote M2 macrophage polarizationFrontiers in immunology · 2022Article
- Effects of Natural Progesterone and Synthetic Progestin on Germ Layer Gene Expression in a Human Embryoid Body Model.International journal of molecular sciences · 2020Article
- Animal Models for Human Polycystic Ovary Syndrome (PCOS) Focused on the Use of Indirect Hormonal Perturbations: A Review of the Literature.International journal of molecular sciences · 2019Review
- Endometrial Stem Cells and Their Applications in Intrauterine Adhesion.Cell transplantationReview
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThin or damaged endometrium causes uterine factor-derived infertility resulting in a failure of embryonic implantation. Regeneration of endometrium is a major issue in gynecology and reproductive medicine. Various types of cells and scaffolds were studied to establish an effective therapeutic strategy. For this type of investigations, production of optimal animal models is indispensable. In this study, we tried to establish various murine uterine damage models and compared their features.
methodsThree to ten-week-old C57BL/6 female mice were anesthetized using isoflurane. Chemical and mechanical methods using ethanol (EtOH) at 70 or 100% and copper scraper were compared to determine the most efficient condition. Damage of uterine tissue was induced either by vaginal or dorsal surgical approach. After 7-10 days, gross and microscopic morphology, safety and efficiency were compared among the groups.
resultsBoth chemical and mechanical methods resulted in thinner endometrium and reduced number of glands. Gross morphology assessment revealed that the damaged regions of uteri showed various shapes including shrinkage or cystic dilatation of uterine horns. The duration of anesthesia significantly affected recovery after procedure. Uterine damage was most effectively induced by dorsal approach using 100% EtOH treatment compared to mechanical methods.
conclusionTaken together, murine uterine damage models were most successfully established by chemical treatment. This production protocols could be applied further to larger animals such as non-human primate.
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