ArticleJournal of pharmacopuncture2019
Effects of Omeprazole and Caffeine Alone and in Combination with Gentamicin and Ciprofloxacin Against Antibiotic Resistant
Article in Journal of pharmacopuncture, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Supercritical CORSC advances · 2026Article
- A Novel Synergistic Carvacrol-Graphene Oxide-Chitosan Nanocomposite for Effective Root Canal Disinfection.International journal of dentistry · 2026Article
- Exploring caffeine as a disruptor of membrane integrity and genomic stability in Staphylococcus aureus: functional and in silico analysis.Archives of microbiology · 2025Article
- Mechanism of antibacterial phytoconstituents: an updated review.Archives of microbiology · 2024Review
- Article
- Enhancing bactericidal activities of ciprofloxacin by targeting the trans-translation system that is involved in stress responses in Klebsiella pneumoniae.Archives of microbiology · 2024Article
- Synergistic antibacterial activity of carvacrol loaded chitosan nanoparticles with Topoisomerase inhibitors and genotoxicity evaluation.Saudi journal of biological sciences · 2023Article
- Antioxidant and Antibacterial Properties of a Functional Sports Beverage Formulation.International journal of molecular sciences · 2023Article
- The Antifungal and Antibiofilm Activities of Caffeine againstBiomedicines · 2022Article
- The Highest Dosage Combination Activity Screening from the Leaf Fraction ofJournal of pharmacopuncture · 2022Article
- Dietary Protein, Fiber and Coffee Are Associated with Small Intestine Microbiome Composition and Diversity in Patients with Liver Cirrhosis.Nutrients · 2020Article
- Caffeine and its main targets of colorectal cancer.World journal of gastrointestinal oncology · 2020Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveAntibiotic resistance is a global health problem and threatens health of societies. These problems have led to a search for alternative approaches such as combination therapy. The aim of the present study was to investigate the effect of caffeine and omeprazole in combination with gentamicin or ciprofloxacin against standard and clinically resistant isolates of
methodsThe minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values of different agents against bacterial strains were determined. The interaction of non- antibiotic drugs with gentamicin and ciprofloxacin was studied
resultsThe MIC and MBC values of gentamicin against bacterial strains were in the range of 20- 80 μg/ml and 40-200 μg/ml, respectively. Caffeine and omeprazole had no intrinsic inhibitory activity against tested microorganisms. However, upon combination of caffeine with antibiotics, the synergistic effects were observed. Verapamil was able to reduce the MIC values of gentamicin (4 folds) only in some bacterial strains.
conclusionThese findings indicated that caffeine was effective in removing bacterial infection caused by
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