Evidence map›Paper›PMID 30988998›Full record

ArticleJournal of pharmacopuncture2019

Differential Expression of HSP90

Fereshte Jokar, Javad Amini Mahabadi, Morteza Salimian, Aliakbar Taherian, Seyyed Mohammad Gheibi Hayat, Amirhossein Sahebkar, Mohammad Ali Atlasi

Open access · diamondAbstract read
In one paragraph

Article in Journal of pharmacopuncture, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Fereshte JokarAnatomical Sciences Research Center, Kashan University of Medical sciences, Kashan, Iran.
Javad Amini MahabadiGametogenesis Research Center, Kashan University of Medical Sciences, Kashan, Iran.
Morteza SalimianPlatelet Research Laboratory, Kashan University of Medical Science, Kashan, Iran.
Aliakbar TaherianAnatomical Sciences Research Center, Kashan University of Medical sciences, Kashan, Iran.
Seyyed Mohammad Gheibi HayatDepartment of Medical Genetics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Amirhossein SahebkarNeurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Mohammad Ali AtlasiAnatomical Sciences Research Center, Kashan University of Medical sciences, Kashan, Iran.
Kashan University of Medical Sciences · IRMashhad University of Medical Sciences · IRShahid Sadoughi University of Medical Sciences and Health Services · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBreast cancer is a complex, heterogeneous disease and one of the most common malignancies in women worldwide. The efficacy of chemotherapy as an important breast cancer treatment option has been severely limited because of the inherent or acquired resistance of cancer cells. The molecular chaperone heat shock protein 90 (HSP90) upregulated in response to cellular stress is required for functions such as conformational maturation, activation and stability in more than 200 client proteins, mostly of the signaling type. In this study, the expression of HSP90 isoforms including HSP90α and HSP90 MATERIAL AND

methodsThe cell cytotoxicity of DOX in MDA-MB-231 and MCF-7 cell lines was determined using the MTT assay. Immunofluorescence and western blotting techniques were used to determine the expression of HSP90

resultsThe MTT assay results showed that the MDA-MB- 231 cells (IC

Indexed as

breast cancerheat shock proteinHSP90αHSP90βMCF-7MDA-MB-231

Identifiers

PMID30988998
PMCPMC6461302
OpenAlexW2926346373

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.