ArticleExperimental and therapeutic medicine2019
Establishment of an osteoporosis model in tree shrews by bilateral ovariectomy and comprehensive evaluation.
Article in Experimental and therapeutic medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Wubi Shanyao Pills ameliorate glucocorticoid-induced osteoporosis by regulating bone marrow T cell homing as an immune intermediate to restore bone metabolism.Chinese medicine · 2026Article
- Animal models for age-related osteoporosis.Gerontology · 2025Review
- Tree shrew as a new animal model for musculoskeletal disorders and aging.Bone research · 2025Article
- Study of tree shrew biology and models: A booming and prosperous field for biomedical research.Zoological research · 2024Review
- Sinomenine increases osteogenesis in mice with ovariectomy-induced bone loss by modulating autophagy.World journal of stem cells · 2024Article
- Promoting osteointegration effect of Cu-alloyed titanium in ovariectomized rats.Regenerative biomaterials · 2022Article
- A tree shrew model for steroid-associated osteonecrosis.Zoological research · 2020Article
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22 authors.
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Abstract
Osteoporosis (OP) treatment has always been challenging for elderly menopausal females. An animal model with a closer genetic association to human OP is essential for treatment research. Given its close genetic association to primates, the tree shrew is a suitable candidate for meeting the requirements for such an animal model. In the present study, a tree shrew OP model induced by ovariectomy (OVX), was established. Evaluation by multiple analysis methods, including blood biochemical indicators, uterus coefficients, micro-computed tomography analysis, histochemical analysis and scanning electron microscopic observation indicated that OVX was an appropriate method to establish the OP model in tree shrews. In addition, the biomolecular characteristics of OVX-induced osteoporosis were also assessed by transcriptome sequencing and bioinformatics analysis. The present study provides the methods used to confirm the successful establishment of the OP model in tree shrew, and suggests that the OP model is appropriate for human OP research.
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