Evidence map›Paper›PMID 30988612›Full record

ArticleInternational journal of nanomedicine2019

One-step mechanochemical preparation and prominent antitumor activity of SN-38 self-micelle solid dispersion.

Xuanrong Sun, Dabu Zhu, Yue Cai, Guobang Shi, Mengshi Gao, Minzi Zheng

Open access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Xuanrong SunCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310006, China, sunxr@zjut.edu.cn.
Dabu ZhuCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310006, China, sunxr@zjut.edu.cn.
Yue CaiCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310006, China, sunxr@zjut.edu.cn.
Guobang ShiCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310006, China, sunxr@zjut.edu.cn.
Mengshi GaoCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310006, China, sunxr@zjut.edu.cn.
Minzi ZhengCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310006, China, sunxr@zjut.edu.cn.
Zhejiang University of Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe purpose of this study was to overcome the clinical defects of 7-ethyl-10-hydroxycamptothecin (SN-38) and explore its characteristics and antitumor effects. MATERIALS AND

methodsAn amorphous solid dispersion of SN-38 with disodium glycyrrhizin (Na

resultsSN-38 loaded in Na

conclusionNa

Indexed as

MicellesAnimalsBiological AvailabilityFemaleHumansIrinotecanLung NeoplasmsMaleMiceMice, Inbred BALB CNanoparticlesRatsRats, Sprague-DawleyTissue DistributionTopoisomerase I InhibitorsTumor Cells, CulturedIrinotecanMicellesTopoisomerase I Inhibitorsantitumor efficacycell-micellecytotoxicmechanical ball millingpharmacokineticsSN-38solid dispersiontissue distribution

Identifiers

PMID30988612
PMCPMC6440449
OpenAlexW2923820573

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.