Evidence map›Paper›PMID 30988610›Full record

ArticleInternational journal of nanomedicine2019

Di-

Thomas Briot, Emilie Roger, Naila Bou Haidar, Jerome Bejaud, Nolwenn Lautram, Catherine Guillet, Sylvain Thépot, Samuel Legeay, Frederic Lagarce

Abstract read
In one paragraph

Article in International journal of nanomedicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Thomas BriotMicro & Nanomédecines Translationelles - MINT, UNIV Angers, INSERM 1066, CNRS 6021, University of Angers, MINT IBS-CHU, Larrey, 49933 Angers, France, frederic.lagarce@univ-angers.fr.
Emilie RogerMicro & Nanomédecines Translationelles - MINT, UNIV Angers, INSERM 1066, CNRS 6021, University of Angers, MINT IBS-CHU, Larrey, 49933 Angers, France, frederic.lagarce@univ-angers.fr.
Naila Bou HaidarMicro & Nanomédecines Translationelles - MINT, UNIV Angers, INSERM 1066, CNRS 6021, University of Angers, MINT IBS-CHU, Larrey, 49933 Angers, France, frederic.lagarce@univ-angers.fr.
Jerome BejaudMicro & Nanomédecines Translationelles - MINT, UNIV Angers, INSERM 1066, CNRS 6021, University of Angers, MINT IBS-CHU, Larrey, 49933 Angers, France, frederic.lagarce@univ-angers.fr.
Nolwenn LautramMicro & Nanomédecines Translationelles - MINT, UNIV Angers, INSERM 1066, CNRS 6021, University of Angers, MINT IBS-CHU, Larrey, 49933 Angers, France, frederic.lagarce@univ-angers.fr.
Catherine GuilletUniversity of Angers, Molecular and Cellular Analysis Platform, IBS-CHU, 49933 Angers, France.
Sylvain ThépotUniversity Hospital of Angers, Hematology, 49933 Angers, France.
Samuel LegeayMicro & Nanomédecines Translationelles - MINT, UNIV Angers, INSERM 1066, CNRS 6021, University of Angers, MINT IBS-CHU, Larrey, 49933 Angers, France, frederic.lagarce@univ-angers.fr.
Frederic LagarceMicro & Nanomédecines Translationelles - MINT, UNIV Angers, INSERM 1066, CNRS 6021, University of Angers, MINT IBS-CHU, Larrey, 49933 Angers, France, frederic.lagarce@univ-angers.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute myeloid leukemia mainly affects adult patients. Complete remission for patients younger than 60 years, who are candidates for standard induction therapy, is achieved in 60%-80% of cases. However, the prognosis is still poor for older patients, who are unfit for intensive chemotherapy, and only a few therapies are available. Hypomethylating agents, such as decitabine, are approved for such patients. The current dosing regimen consists of one administration per day, for 5 days, each 4 weeks.

methodsHere, we present the synthesis of a decitabine prodrug, combined with its encapsulation into a lipid-based nanocapsule formulation. Decitabine (C12)

resultsDecitabine (C12)

conclusionDecitabine (C12)

Indexed as

AnimalsAntimetabolites, AntineoplasticCell CycleCell ProliferationDecitabineDrug StabilityHumansLeukemia, Erythroblastic, AcuteLipidsMaleNanocapsulesPlasmaRatsRats, WistarTissue DistributionTumor Cells, CulturedAntimetabolites, AntineoplasticDecitabineLipidsNanocapsulesacute myeloid leukemiadecitabinelipid nanocapsulesnanomedicinesprodrugs

Identifiers

PMID30988610
PMCPMC6440450

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.