ArticleNature neuroscience2019
Serotonin-mediated inhibition of ventral hippocampus is required for sustained goal-directed behavior.
Article in Nature neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 100 citations in OpenAlex.
- The ventral hippocampus: computations, circuits and functions.Nature reviews. Neuroscience · 2026Review
- Neural circuits regulating activity-based anorexia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Individual differences in prosocial learning are represented in the hippocampal dorsal CA1.Nature neuroscience · 2026Article
- Hierarchical Distribution of Reward Representation in the Cortical and Hippocampal Regions.eNeuro · 2026Article
- The Serotonin 1B Receptor Modulates Striatal Activity Differentially Based on Behavioral Context.eNeuro · 2026Article
- Serotonin suppresses cortical theta bursts during NREM sleep.Frontiers in pharmacology · 2026Article
- microRNA-17-5p modulates ventral hippocampal transcriptome and synaptic proteome: Implications for emotional regulation in adult male rats.Neurobiology of disease · 2026Article
- Complementary roles of dorsal and ventral hippocampus in the flexible adaptation of goal-directed behavior.Science advances · 2025Article
- The serotonin 1B receptor modulates striatal activity differentially based on behavioral context.bioRxiv : the preprint server for biology · 2025Article
- Review
- Serotonin Modulation of Dorsoventral Hippocampus in Physiology and Schizophrenia.International journal of molecular sciences · 2025Review
- Ventral hippocampus neurons encode meal-related memory.Nature communications · 2025Article
- Article
- Reward integration in prefrontal-cortical and ventral-hippocampal nucleus accumbens inputs cooperatively modulates engagement.Nature communications · 2025Article
- Article
- Deciphering the Functions of Raphe-Hippocampal Serotonergic and Glutamatergic Circuits and Their Deficits in Alzheimer's Disease.International journal of molecular sciences · 2025Review
- Serotonin modulates infraslow oscillation in the dentate gyrus during Non-REM sleep.bioRxiv : the preprint server for biology · 2025Article
- Differences in firing patterns along the dorsal-intermediate hippocampal axis in a fixed route during a change in emotional context.Frontiers in systems neuroscience · 2025Article
- Optogenetic activation of serotonergic neurons changes masticatory movement in freely moving mice.Scientific reports · 2024Article
- Sex-biased neural encoding of threat discrimination in nucleus accumbens afferents drives suppression of reward behavior.Nature neuroscience · 2024Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The ability to sustain goal-directed action is essential for success in many domains, but little is known about the corresponding neural substrates. Using fiber photometry to monitor population neural activity, we demonstrate that engagement in sustained food- or punishment-motivated behavior is associated with suppression of ventral but not dorsal hippocampal activity. Using optogenetic stimulation, we demonstrate that this suppression is required for goal-directed behavior, whereas optogenetic suppression of the ventral hippocampus (vHP) enhances the ability to sustain goal-directed behavior. Suppression of vHP during sustained goal-directed behavior was accompanied by increased activity in median but not dorsal raphe, implicating serotonergic signaling through Htr3a as a mechanism of vHP suppression during successful goal-directed behavior. Sustainment of goal-directed action may require suppression of vHP because of the structure's well-documented role in behavioral inhibition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.