ArticleEye (London, England)2019
Comparison between patient-reported outcomes after enucleation and proton beam radiotherapy for uveal melanomas: a 2-year cohort study.
Article in Eye (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Quality of life with anophthalmia: a systematic review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Pooled it
- Quality of life among people with eye cancer: a systematic review from 2012 to 2022.Health and quality of life outcomes · 2024Pooled it
- Predictors of emotional distress in uveal melanoma survivors: a systematic review.Eye (London, England) · 2023Pooled it
- Dosimetric feasibility of carbon-ion radiotherapy for ocular melanomas with local effect model-based treatment planning system.Journal of radiation research · 2026Article
- Choroidal melanoma patient views on the importance of treatment characteristics and outcomes, and physicians' information provision in the Netherlands.Acta ophthalmologica · 2025Article
- Reliability, validity, and acceptability of the simplified Mandarin Chinese EORTC QLQ-OPT30 for uveal melanoma patients.Scientific reports · 2025Article
- Health related quality of life and its influencing factors in Chinese patients with ocular tumors.Scientific reports · 2025Article
- Timing of eye removal influences low-vision quality of life and self-perception of facial appearance in people with one eye.PloS one · 2025Article
- Observational
- Depression and anxiety in patients with uveal melanoma undergoing curative proton treatment-A prospective study.Cancer reports (Hoboken, N.J.) · 2023Article
- Impact of Adjuvant Ocular Interventions on the Quality of Life of Patients with Uveal Melanoma after Proton Beam Therapy.Ocular oncology and pathology · 2022Article
- Clinical Outcomes after International Referral of Uveal Melanoma Patients for Proton Therapy.Cancers · 2021Article
- Quality of life and treatment-related burden during ocular proton therapy: a prospective trial of 131 patients with uveal melanoma.Radiation oncology (London, England) · 2021Article
- Differentiating Choroidal Melanomas and Nevi Using a Self-Supervised Deep Learning Model Applied to Clinical Fundoscopy Images.Ophthalmology scienceArticle
- Two 11-Years Periods Statistics and Trends of Enucleation and Evisceration.The Journal of craniofacial surgeryArticle
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUveal melanomas affect 2-8 per million Europeans each year. Approximately 35%, are treated by enucleation. Proton beam radiotherapy (PBR) can be an eye-conserving alternative to enucleation for patients who wish to retain the eye. Both treatments have adverse effects, and it is difficult for clinicians and patients to make fully informed choices between them because the relative effects of enucleation and PBR on patient-reported outcomes are unknown.
methodsWe compared differential effects of enucleation and PBR on patient-reported outcomes on the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Ophthalmological module (EORTC QLQ- OPT30) in a consecutive sample of 115 treated patients ~ 6, 12 and 24 months after diagnosis. Pre-treatment demographic variables, unrelated health problems, vision in the fellow eye, tumour characteristics and prognosis for metastatic disease were statistically controlled.
resultsPatients treated by enucleation experienced greater functional problems at 6 months, which abated at 12 and 24 months (P = 0.020). PBR patients reported greater impairments of central and peripheral vision (P = 0.009) and reading difficulties (P = 0.002) over 24 months. Treatment modality did not influence difficulty in driving (P = 0.694), ocular irritation (P = 0.281), headaches (P = 0.640), appearance concerns (P = 0.187) or worry about recurrence (P = 0.899).
conclusionsWhen making treatment decisions, it is important that patients and clinicians consider long-standing difficulties of visual impairment associated with PBR and temporary 6-month difficulties in activities related to depth perception associated with enucleation.
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