ReviewActa crystallographica. Section D, Structural biology2019
A structural overview of the zinc transporters in the cation diffusion facilitator family.
Review in Acta crystallographica. Section D, Structural biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 56 citations in OpenAlex.
- Manganese: biology, physiology and role in disease.Cell discovery · 2026Review
- The Rare Earth Element Lanthanum (La) Accumulates inPlants (Basel, Switzerland) · 2025Article
- Proteomics analysis in rats reveals convergent mechanisms between major depressive disorder and dietary zinc deficiency.Pharmacological reports : PR · 2025Article
- Zinc and its binding proteins: essential roles and therapeutic potential.Archives of toxicology · 2025Review
- Unravelling the antitumor mechanism of Ocoxin through cancer cell genomics.Frontiers in pharmacology · 2025Article
- Structural insights into the calcium-coupled zinc export of human ZnT1.Science advances · 2024Article
- Structures, Mechanisms, and Physiological Functions of Zinc Transporters in Different Biological Kingdoms.International journal of molecular sciences · 2024Review
- Energy coupling and stoichiometry of ZneLife · 2023Article
- A bioinformatic analysis of zinc transporters in intestinal Lactobacillaceae.Metallomics : integrated biometal science · 2023Article
- Safe Production Strategies for Soil-Covered Cultivation of Morel in Heavy Metal-Contaminated Soils.Journal of fungi (Basel, Switzerland) · 2023Review
- Characterization of three predicted zinc exporters inFrontiers in veterinary science · 2023Article
- Article
- Proteomic Characterization of Virulence Factors and Related Proteins inInternational journal of molecular sciences · 2022Article
- Zinc in Cognitive Impairment and Aging.Biomolecules · 2022Review
- Comparative and Systematic Omics Revealed Low Cd Accumulation of PotatoInternational journal of molecular sciences · 2021Article
- Zinc binding alters the conformational dynamics and drives the transport cycle of the cation diffusion facilitator YiiP.The Journal of general physiology · 2021Article
- Loss of Znt8 function in diabetes mellitus: risk or benefit?Molecular and cellular biochemistry · 2021Review
- Insights into the Dynamics of the Human Zinc Transporter ZnT8 by MD Simulations.Journal of chemical information and modeling · 2021Article
- Heterologous Expression and Biochemical Characterization of the Human Zinc Transporter 1 (ZnT1) and Its Soluble C-Terminal Domain.Frontiers in chemistry · 2021Article
- The cation diffusion facilitator protein MamM's cytoplasmic domain exhibits metal-type dependent binding modes and discriminates against MnThe Journal of biological chemistry · 2020Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The cation diffusion facilitators (CDFs) are a family of membrane-bound proteins that maintain cellular homeostasis of essential metal ions. In humans, the zinc-transporter CDF family members (ZnTs) play important roles in zinc homeostasis. They do this by facilitating zinc efflux from the cytoplasm to the extracellular space across the plasma membrane or into intracellular organelles. Several ZnTs have been implicated in human health owing to their association with type 2 diabetes and neurodegenerative diseases. Although the structure determination of CDF family members is not trivial, recent advances in membrane-protein structural biology have resulted in two structures of bacterial YiiPs and several structures of their soluble C-terminal domains. These data reveal new insights into the molecular mechanism of ZnT proteins, suggesting a unique rocking-bundle mechanism that provides alternating access to the metal-binding site.
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