ArticleProceedings of the National Academy of Sciences of the United States of America2019
How a well-adapting immune system remembers.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
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- Limits on the computational expressivity of non-equilibrium biophysical processes.Nature communications · 2025Article
- Soft Modes as a Predictive Framework for Low-Dimensional Biological Systems Across Scales.Annual review of biophysics · 2025Review
- Soft Modes as a Predictive Framework for Low Dimensional Biological Systems across Scales.ArXiv · 2024Article
- Size Tuning of Mesoporous Silica Adjuvant for One-Shot Vaccination with Long-Term Anti-Tumor Effect.Pharmaceutics · 2024Article
- Steering and controlling evolution - from bioengineering to fighting pathogens.Nature reviews. Genetics · 2023Review
- An inference model gives insights into innate immune adaptation and repertoire diversity.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
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- Cell Decision Making through the Lens of Bayesian Learning.Entropy (Basel, Switzerland) · 2023Article
- Social Safety Theory: Conceptual foundation, underlying mechanisms, and future directions.Health psychology review · 2023Article
- Modeling and predicting the overlap of B- and T-cell receptor repertoires in healthy and SARS-CoV-2 infected individuals.PLoS genetics · 2023Article
- Inferring the T cell repertoire dynamics of healthy individuals.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Measures of epitope binding degeneracy from T cell receptor repertoires.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
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- Two types of human TCR differentially regulate reactivity to self and non-self antigens.iScience · 2022Article
- Two complementary features of humoral immune memory confer protection against the same or variant antigens.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An adaptive agent predicting the future state of an environment must weigh trust in new observations against prior experiences. In this light, we propose a view of the adaptive immune system as a dynamic Bayesian machinery that updates its memory repertoire by balancing evidence from new pathogen encounters against past experience of infection to predict and prepare for future threats. This framework links the observed initial rapid increase of the memory pool early in life followed by a midlife plateau to the ease of learning salient features of sparse environments. We also derive a modulated memory pool update rule in agreement with current vaccine-response experiments. Our results suggest that pathogenic environments are sparse and that memory repertoires significantly decrease infection costs, even with moderate sampling. The predicted optimal update scheme maps onto commonly considered competitive dynamics for antigen receptors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.