Evidence map›Paper›PMID 30988194›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

DNA threads released by activated CD4

Massimo Costanza, Pietro L Poliani, Paola Portararo, Barbara Cappetti, Silvia Musio, Francesca Pagani, Lawrence Steinman, Mario P Colombo, Rosetta Pedotti, Sabina Sangaletti

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 39 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Allergen-induced DNA release by the airway epithelium amplifies type 2 immunity.The Journal of allergy and clinical immunology · 2023
    Article
  9. Article
  10. Pathogenesis of pneumonia and acute lung injury.Clinical science (London, England : 1979) · 2022
    Review
  11. Article
  12. Review
  13. Frontiers in immunology · 2022
    Article
  14. Review
  15. Review
  16. Article
  17. Microglia activation: a role for mitochondrial DNA?Neural regeneration research · 2021
    Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Massimo CostanzaDepartment of Clinical Neuroscience, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy; massimo.costanza@istituto-besta.it steinman@stanford.edu.ORCID 0000-0002-1673-8574
Pietro L PolianiDepartment of Molecular and Translational Medicine, Pathology Unit, University of Brescia, 25121 Brescia, Italy.ORCID 0000-0002-5662-8978
Paola PortararoDepartment of Research, Molecular Immunology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy.
Barbara CappettiDepartment of Research, Molecular Immunology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy.
Silvia MusioDepartment of Clinical Neuroscience, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.
Francesca PaganiDepartment of Molecular and Translational Medicine, Pathology Unit, University of Brescia, 25121 Brescia, Italy.
Lawrence SteinmanDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305 massimo.costanza@istituto-besta.it steinman@stanford.edu.
Mario P ColomboDepartment of Research, Molecular Immunology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy.ORCID 0000-0003-0042-7955
Rosetta PedottiDepartment of Clinical Neuroscience, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy.
Sabina SangalettiDepartment of Research, Molecular Immunology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy.
Fondazione IRCCS Istituto Nazionale dei Tumori · ITFondazione IRCCS Istituto Neurologico Carlo Besta · ITUniversity of Brescia · ITStanford University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The extrusion of DNA traps contributes to a key mechanism in which innate immune cells clear pathogens or induce sterile inflammation. Here we provide evidence that CD4

Indexed as

AnimalsAutocrine CommunicationCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell-Free Nucleic AcidsCentral Nervous SystemDisease Models, AnimalDNAEncephalomyelitis, Autoimmune, ExperimentalInflammationMiceMice, Inbred C57BLMultiple SclerosisMyelin-Oligodendrocyte GlycoproteinMyelin SheathCell-Free Nucleic AcidsDNAMyelin-Oligodendrocyte GlycoproteinautoimmunityCD4+ T cellsDNA threadsEAEmultiple sclerosis

Identifiers

PMID30988194
PMCPMC6500139
OpenAlexW2938590585

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.