Evidence map›Paper›PMID 30988141›Full record

ArticleAntimicrobial agents and chemotherapy2019

Treatment with the Pseudomonas aeruginosa Glycoside Hydrolase PslG Combats Wound Infection by Improving Antibiotic Efficacy and Host Innate Immune Activity.

Matthew J Pestrak, Perrin Baker, Sheri Dellos-Nolan, Preston J Hill, Daniel Passos da Silva, Holly Silver, Ira Lacdao, Deepa Raju, Matthew R Parsek, Daniel J Wozniak and 1 more

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. PslG-Mediated Disruption ofInternational journal of molecular sciences · 2026
    Article
  3. Living Microbial Drugs.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Phage-Based Approaches to ChronicAntibiotics (Basel, Switzerland) · 2026
    Review
  8. Review
  9. Article
  10. Article
  11. Biofilm · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. A bacterial pigment provides cross-species protection from HProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Matthew J PestrakDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0002-7609-7537
Perrin BakerMolecular Medicine, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada.
Sheri Dellos-NolanDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio, USA.
Preston J HillDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio, USA.
Daniel Passos da SilvaDepartment of Microbiology, University of Washington, Seattle, Washington, USA.
Holly SilverDepartment of Microbiology, University of Washington, Seattle, Washington, USA.
Ira LacdaoMolecular Medicine, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada.
Deepa RajuMolecular Medicine, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada.
Matthew R ParsekDepartment of Microbiology, University of Washington, Seattle, Washington, USA parsem@uw.edu Daniel.Wozniak@osumc.edu howell@sickkids.ca.
Daniel J WozniakDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio, USA parsem@uw.edu Daniel.Wozniak@osumc.edu howell@sickkids.ca.
P Lynne HowellMolecular Medicine, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada parsem@uw.edu Daniel.Wozniak@osumc.edu howell@sickkids.ca.

Funding

The pel exopolysaccharide gene cluster of Pseudomonas aeruginosaR01AI077628 · NIAID · UNIVERSITY OF WASHINGTON · PI MATTHEW R. PARSEK, Daniel J Wozniak · 2009 to 2026
$7.1M
Revisiting alginate paradigmsR01AI134895 · NIAID · OHIO STATE UNIVERSITY · PI WOZNIAK, DANIEL J · 2018 to 2022
$2.5M
Enzyme therapeutics for biofilm prevention and disruptionR33AI119116 · NIAID · HOSPITAL FOR SICK CHLDRN (TORONTO) · PI HOWELL, PATRICIA LYNNE · 2017 to 2019
$904k
Enzyme therapeutics for biofilm prevention and disruptionR21AI119116 · NIAID · HOSPITAL FOR SICK CHLDRN (TORONTO) · PI HOWELL, PATRICIA LYNNE · 2015 to 2016
$445k
CIHR FDN154327NIAID NIH HHS R01 AI077628NIAID NIH HHS R01 AI134895NIAID NIH HHS R21 AI119116NIAID NIH HHS R33 AI119116
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsAnti-Bacterial AgentsBiofilmsFemaleGlycoside HydrolasesHumansImmunity, InnateMiceMice, Inbred BALB CNeutrophilsPhagocytosisPseudomonas aeruginosaPseudomonas InfectionsReactive Oxygen SpeciesSwineTobramycinAnti-Bacterial AgentsGlycoside HydrolasesReactive Oxygen SpeciesTobramycinbiofilmexopolysaccharideglycoside hydrolasePseudomonas aeruginosaPsltherapeuticwound infection

Identifiers

PMID30988141
PMCPMC6535529

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.