Evidence map›Paper›PMID 30988140›Full record

ArticleAntimicrobial agents and chemotherapy2019

Tissue Distribution and Penetration of Isavuconazole at the Site of Infection in Experimental Invasive Aspergillosis in Mice with Underlying Chronic Granulomatous Disease.

Annie Lee, Brendan Prideaux, Min Hee Lee, Matthew Zimmerman, Enriko Dolgov, David S Perlin, Yanan Zhao

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 24 citations in OpenAlex.

  1. Challenges and opportunities in the management of severe pneumonia. Key concepts from the Seventh Annual Meeting of Spanish Experts 2025.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2026
    Review
  2. Article
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  11. Isavuconazole Diffusion in Infected Human Brain.Antimicrobial agents and chemotherapy · 2019
    Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Annie LeePublic Health Research Institute, Rutgers Biomedical and Health Sciences, Newark, New Jersey, USA.
Brendan PrideauxPublic Health Research Institute, Rutgers Biomedical and Health Sciences, Newark, New Jersey, USA.
Min Hee LeePublic Health Research Institute, Rutgers Biomedical and Health Sciences, Newark, New Jersey, USA.
Matthew ZimmermanPublic Health Research Institute, Rutgers Biomedical and Health Sciences, Newark, New Jersey, USA.
Enriko DolgovPublic Health Research Institute, Rutgers Biomedical and Health Sciences, Newark, New Jersey, USA.
David S PerlinPublic Health Research Institute, Rutgers Biomedical and Health Sciences, Newark, New Jersey, USA.
Yanan ZhaoPublic Health Research Institute, Rutgers Biomedical and Health Sciences, Newark, New Jersey, USA yanan.zhao@hackensackmeridian.org.
Rutgers HealthRutgers, The State University of New Jersey · US

Funding

A QTRAP 6500 LC-MS/MS System from SCIEX for high accuracy drug content analysisS10OD023524 · OD · RBHS-NEW JERSEY MEDICAL SCHOOL · PI DARTOIS, VERONIQUE · 2017 to 2017
$526k
A MALDI LTQ Orbitrap XL Mass Spectrometer for BioImagingS10OD018072 · OD · RBHS-NEW JERSEY MEDICAL SCHOOL · PI DARTOIS, VERONIQUE · 2015 to 2015
$418k
6 · The paper itself

Abstract

Isavuconazole, the active moiety of the prodrug isavuconazonium sulfate, has potent activity against a wide spectrum of fungal pathogens and is approved for the treatment of invasive aspergillosis, yet little is known about the tissue penetration of isavuconazole at the target sites of infection. Here, we explored the spatial and quantitative distribution of isavuconazole in tissue lesions in experimental pulmonary aspergillosis established in mice with chronic granulomatous disease (CGD) (gp91

Indexed as

Administration, OralAnimalsAntifungal AgentsAspergillosisChromatography, LiquidDisease Models, AnimalGranulomatous Disease, ChronicInvasive Fungal InfectionsMaleMiceNitrilesProdrugsPyridinesTandem Mass SpectrometryTissue DistributionTriazolesAntifungal AgentsisavuconazoleNitrilesProdrugsPyridinesTriazoleschronic granulomatous diseasedrug penetrationinvasive aspergillosisisavuconazoleisavuconazonium sulfatelaser capture microdissectionmatrix-assisted laser desorption ionization mass spectrometry imaging

Identifiers

PMID30988140
PMCPMC6535567
OpenAlexW2936626152

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.