Associations between cytotoxic T-lymphocyte-associated antigen 4 gene polymorphisms and diabetes mellitus: a meta-analysis of 76 case-control studies.

Open access · goldAbstract readMeta-AnalysisSystematic Review

In one paragraph

Synthesis in Bioscience reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it

0cells of the map it votes in

5citing papers in PubMed

0.7field-weighted citation impact, top 25% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

Association between CTLA-4 gene polymorphisms and Type 1 diabetes in Kurdish patients.Frontiers in endocrinology · 2026
Article
Identifying genetically predisposed type 1 diabetes mellitus individuals in a Southern Brazilian population: The construction of a genetic risk score.Genetics and molecular biology · 2025
Article
Functional Impact of Risk Gene Variants on the Autoimmune Responses in Type 1 Diabetes.Frontiers in immunology · 2022
Review
Autoimmune thyroid disease and type 1 diabetes mellitus: same pathogenesis; new perspective?Therapeutic advances in endocrinology and metabolism · 2020
Review
Genetic Association Study of IL2RA, IFIH1, and CTLA-4 Polymorphisms With Autoimmune Thyroid Diseases and Type 1 Diabetes.Frontiers in pediatrics · 2020
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Min ChenDepartment of Internal Medicine, Ningbo No. 6 Hospital, Ningbo 315040, Zhejiang, China lishumin9982@163.com.

ShuMin LiDepartment of Internal Medicine, Ningbo No. 6 Hospital, Ningbo 315040, Zhejiang, China lishumin9982@163.com.ORCID 0000-0002-1858-4927

Ningbo No.6 Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Genetic Predisposition to DiseasePolymorphism, GeneticAsian PeopleCase-Control StudiesCTLA-4 AntigenDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2Genetic MarkersHumansWhite PeopleCTLA-4 AntigenCTLA4 protein, humanGenetic MarkersCytotoxic T-lymphocyte-associated antigen 4 (CTLA-4)Diabetes mellitus (DM)Gene polymorphismsMeta-analysis

Identifiers

PMID30988065

DOI10.1042/BSR20190309

PMCPMC6522704

OpenAlexW2937846539

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.