Evidence map›Paper›PMID 30988052›Full record

ArticleThe Journal of experimental medicine2019

T cell anergy in perinatal mice is promoted by T reg cells and prevented by IL-33.

Jonatan Tuncel, Christophe Benoist, Diane Mathis

Abstract read
In one paragraph

Article in The Journal of experimental medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Article
  2. Neonatal liver niches program T cell tolerance.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. Seeding of visceral adipose tissue with perinatally generated regulatory T cells shapes the metabolic tenor in mice.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Review
  7. Review
  8. Article
  9. Lymph node stromal cell responses to perinatal T cell waves, a temporal atlas.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  10. BATF represses BIM to sustain tolerant T cells in the periphery.The Journal of experimental medicine · 2023
    Article
  11. Article
  12. Amphiregulin couples IL1RL1Science advances · 2023
    Article
  13. Review
  14. Treg cells require Izumo1R to regulate γδT cell-driven inflammation in the skin.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  15. PD-1 cooperates with AIRE-mediated tolerance to prevent lethal autoimmune disease.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. RNA Flow Cytometry for the Study of T Cell Metabolism.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jonatan TuncelDepartment of Immunology, Harvard Medical School, Boston, MA.
Christophe BenoistDepartment of Immunology, Harvard Medical School, Boston, MA cbdm@hms.harvard.edu.
Diane MathisDepartment of Immunology, Harvard Medical School, Boston, MA cbdm@hms.harvard.edu.ORCID 0000-0002-6110-4626

Funding

SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI ROHIT N. KULKARNI · 1986 to 2026
$50.5M
AIRE, a zinc-finger protein that controls autoimmunityR01DK060027 · NIDDK · JOSLIN DIABETES CENTER · PI DIANE J MATHIS · 2002 to 2026
$7.4M
Special BD LSRFortessaS10OD021740 · OD · JOSLIN DIABETES CENTER · PI SERWOLD, THOMAS F · 2016 to 2016
$363k
NIDDK NIH HHS P30 DK036836NIDDK NIH HHS R01 DK060027
6 · The paper itself

Abstract

Perinatal T cells broadly access nonlymphoid tissues, where they are exposed to sessile tissue antigens. To probe the outcome of such encounters, we examined the defective elimination of self-reactive clones in Aire-deficient mice. Nonlymphoid tissues were sequentially seeded by distinct waves of CD4

Indexed as

AgingAIRE ProteinAnimalsApoptosisAutoimmunityClonal AnergyCytokinesGene Expression RegulationImmunologic MemoryInterleukin-33LiverLymphocyte ActivationMiceProgrammed Cell Death 1 ReceptorReceptors, Interleukin-1Signal TransductionAIRE ProteinCytokinesInterleukin-33Pdcd1 protein, mouseProgrammed Cell Death 1 ReceptorReceptors, Interleukin-1Transcription Factors

Identifiers

PMID30988052
PMCPMC6547863

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.