Evidence map›Paper›PMID 30988034›Full record

ArticleJournal of bacteriology2019

Guanidine Riboswitch-Regulated Efflux Transporters Protect Bacteria against Ionic Liquid Toxicity.

Douglas A Higgins, John M Gladden, Jeff A Kimbrel, Blake A Simmons, Steven W Singer, Michael P Thelen

Open access · bronzeAbstract read
In one paragraph

Article in Journal of bacteriology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 27 citations in OpenAlex.

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  4. Biomolecular NMR assignments · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Douglas A HigginsThe Joint BioEnergy Institute, Emeryville, California, USA.
John M GladdenThe Joint BioEnergy Institute, Emeryville, California, USA.
Jeff A KimbrelLawrence Livermore National Laboratory, Livermore, California, USA.ORCID 0000-0001-7213-9392
Blake A SimmonsThe Joint BioEnergy Institute, Emeryville, California, USA.
Steven W SingerThe Joint BioEnergy Institute, Emeryville, California, USA.
Michael P ThelenThe Joint BioEnergy Institute, Emeryville, California, USA mthelen@llnl.gov.ORCID 0000-0002-2479-5480
Lawrence Livermore National Laboratory · USLawrence Berkeley National Laboratory · USSandia National Laboratories California · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plant cell walls contain a renewable, nearly limitless supply of sugar that could be used to support microbial production of commodity chemicals and biofuels. Imidazolium ionic liquid (IIL) solvents are among the best reagents for gaining access to the sugars in this otherwise recalcitrant biomass. However, the sugars from IIL-treated biomass are inevitably contaminated with residual IILs that inhibit growth in bacteria and yeast, blocking biochemical production by these organisms. IIL toxicity is, therefore, a critical roadblock in many industrial biosynthetic pathways. Although several IIL-tolerant (IIL

Indexed as

BiofuelsBiomassDrug Resistance, Multiple, BacterialEscherichia coliGene EditingGene Expression Regulation, BacterialGuanidineImidazolesIonic LiquidsMembrane Transport ProteinsMutationRiboswitchBiofuelsGuanidineImidazolesIonic LiquidsMembrane Transport ProteinsRiboswitchBacillusbiofuelsfunctional genomicsguanidine riboswitchionic liquidsquaternary ammonium compounds

Identifiers

PMID30988034
PMCPMC6560137
OpenAlexW2937829816

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.