Evidence map›Paper›PMID 30988030›Full record

ArticleJournal of bacteriology2019

Competence beyond Genes: Filling in the Details of the Pneumococcal Competence Transcriptome by a Systems Approach.

Malcolm E Winkler, Donald A Morrison

Abstract readComment
In one paragraph

Article in Journal of bacteriology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. The global proteome ofFrontiers in cellular and infection microbiology · 2025
    Article
  3. Article
  4. Investigating theMicrobiology (Reading, England) · 2022
    Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Malcolm E WinklerDepartment of Biology, Indiana University Bloomington, Bloomington, Indiana, USA winklerm@indiana.edu.
Donald A MorrisonDepartment of Biological Sciences, University of Illinois at Chicago, Chicago, Illinois, USA.

Funding

New Regulatory Interactions and Circuits that Mediate the Dynamics, Homeostasis, and Stress Responses of Peptidoglycan Synthesis in the Superbug Streptococcus pneumoniaeR35GM131767 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI MALCOLM E. WINKLER · 2019 to 2026
$4.8M
Spaciotemporal Regulation of Specific Penicillin Binding Protein (PBP) Function Determined by New Activity-Based ApproachesR01GM128439 · NIGMS · UNIVERSITY OF MINNESOTA · PI CARLSON, ERIN ELIZABETH, WINKLER, MALCOLM E. · 2018 to 2019
$936k
New Regulatory Circuits that Mediate Peptidoglycan Homeostasis and Cell Wall Stress Responses in the Superbug Streptococcus pneumoniaeR01GM127715 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI WINKLER, MALCOLM E. · 2018 to 2019
$630k
Confined Genetic Transformation and Exchange of Antibiotic Resistance Genes in Femtoliter MicrodropletsR21AI133304 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI EDDINGTON, DAVID · 2017 to 2018
$416k
Mechanism and structure of a novel activator of an alternative Sigma factor regulating competenceR03AI128228 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MORRISON, DONALD · 2017 to 2018
$152k
NIAID NIH HHS R03 AI128228NIAID NIH HHS R21 AI133304NIGMS NIH HHS R01 GM127715NIGMS NIH HHS R01 GM128439NIGMS NIH HHS R35 GM131767
6 · The paper itself

Abstract

DNA uptake by natural competence is a central process underlying the genetic plasticity, biology, and virulence of the human respiratory opportunistic pathogen

Indexed as

RegulonHumansSequence Analysis, RNAStreptococcus pneumoniaeSystems AnalysisTranscriptomegenetic competencepneumococcustranscriptomics

Identifiers

PMID30988030
PMCPMC6560134

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.