Evidence map›Paper›PMID 30987717›Full record

ArticleJournal of food and drug analysis2019

Targeting amine- and phenol-containing metabolites in urine by dansylation isotope labeling and liquid chromatography mass spectrometry for evaluation of bladder cancer biomarkers.

Yi-Ting Chen, Hsin-Chien Huang, Ya-Ju Hsieh, Shu-Hsuan Fu, Liang Li, Chien-Lun Chen, Lichieh Julie Chu, Jau-Song Yu

Open access · hybridAbstract read
In one paragraph

Article in Journal of food and drug analysis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Identifying sex-linked metabolomic biomarkers in fish gonads after bacterial infection.Metabolomics : Official journal of the Metabolomic Society · 2025
    Article
  4. Article
  5. Stereoselective Amine-omics Using Heavy Atom Isotope Labeled l- and d-Marfey's Reagents.Journal of the American Society for Mass Spectrometry · 2024
    Article
  6. Article
  7. Advances in the Clinical Application of High-throughput Proteomics.Exploratory research and hypothesis in medicine
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Yi-Ting ChenGraduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Hsin-Chien HuangMolecular Medicine Research Center, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Ya-Ju HsiehMolecular Medicine Research Center, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Shu-Hsuan FuMolecular Medicine Research Center, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Liang LiDepartment of Chemistry, University of Alberta, Edmonton, AB, T6G2G2, Canada.
Chien-Lun ChenDepartment of Urology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Lichieh Julie ChuMolecular Medicine Research Center, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Jau-Song YuResearch Center for Food and Cosmetic Safety, Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan.
Chang Gung University · TWChang Gung University of Science and Technology · TWUniversity of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metabolomics is considered an effective approach for understanding metabolic responses in complex biological systems. Accordingly, it has attracted increasing attention for biomarker discovery, especially in cancer. In this study, we used a non-invasive method to evaluate four urine metabolite biomarker candidates-o-phosphoethanolamine, 3-amio-2-piperidone, uridine and 5-hydroxyindoleactic acid-for their potential as bladder cancer diagnostic biomarkers. To analyze these targeted amine- and phenol-containing metabolites, we used differential

Indexed as

AminesBiomarkers, TumorChromatography, LiquidDansyl CompoundsHumansIsotope LabelingMass SpectrometryPhenolsQuality ControlUrinary Bladder NeoplasmsAminesBiomarkers, TumorDansyl CompoundsPhenolsBiomarkerBladder cancerMetabolitesPhosphoethanolamineUridine

Identifiers

PMID30987717
PMCPMC9296201
OpenAlexW2910417052

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.