Evidence map›Paper›PMID 30987713›Full record

ArticleJournal of food and drug analysis2019

Rapid identification of herbal toxins using electrospray laser desorption ionization mass spectrometry for emergency care.

Hung Su, Kuan-Ting Liu, Bai-Hsiun Chen, Yen-Ping Lin, Yu-Min Jiang, Yi-Hong Tsai, Fang-Rong Chang, Jentaie Shiea, Chi-Wei Lee

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of food and drug analysis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 15 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Hung SuDepartment of Chemistry, National Sun Yat-Sen University, Kaohsiung, Taiwan.
Kuan-Ting LiuDepartment of Emergency Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Bai-Hsiun ChenDepartment of Laboratory Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Yen-Ping LinDepartment of Chemistry, National Sun Yat-Sen University, Kaohsiung, Taiwan.
Yu-Min JiangDepartment of Chemistry, National Sun Yat-Sen University, Kaohsiung, Taiwan.
Yi-Hong TsaiGraduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan.
Fang-Rong ChangGraduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan.
Jentaie ShieaDepartment of Chemistry, National Sun Yat-Sen University, Kaohsiung, Taiwan.
Chi-Wei LeeResearch Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
National Sun Yat-sen University · TWKaohsiung Medical University · TWKaohsiung Medical University Chung-Ho Memorial Hospital · TWNational Research Institute of Chinese Medicine · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The unintentional ingestion of toxic compounds in herbs is not uncommon in many parts of the world. To provide timely and life-saving care in the emergency department, it is essential to develop a point-of-care analytical method that can rapidly identify these toxins in herbs. Since electrospray laser desorption ionization mass spectrometry (ELDI/MS) has been successfully used to characterize non-volatile chemical compounds without sample preparation, it was used to identify toxic herbal compounds in this study. The herbal toxins were collected either by sweeping a metallic probe across the surface of a freshly cut herb section or by directly sampling extracts of ground herbal powder. The analytes on the probe were then desorbed, ionized and detected using ELDI/MS, wherein analysis of the herbal toxins was completed within 30 s. This approach allows for the rapid morphological recognition of herbs and early point-of-care identification of herbal toxins for emergency management and is promising in providing important toxicological information to ensure appropriate medical treatment.

Indexed as

Emergency Medical ServicesAconitineFlavanonesHumansPlants, ToxicPyridoxineSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationToxins, Biological4'-O-methylpyridoxineAconitineFlavanoneshypaconitinemesaconitinePyridoxineToxins, BiologicalwogoninElectrospray laser desorption ionization mass spectrometryEmergency managementHerbal toxinsPoint-of-care

Identifiers

PMID30987713
PMCPMC9296212
OpenAlexW2907542009

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.