Evidence map›Paper›PMID 30987657›Full record

ArticleCell communication and signaling : CCS2019

Estrogen regulation of cardiac cAMP-L-type Ca

Jeremiah Ong'achwa Machuki, Hong-Yuan Zhang, Juan Geng, Lu Fu, Gabriel Komla Adzika, Lijuan Wu, Wenkang Shang, Jinxia Wu, Li Kexue, Zhiwei Zhao and 1 more

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell communication and signaling : CCS, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 45 citations in OpenAlex.

  1. Uncovering a Sex-Specific cAMP Landscape in Vascular Smooth Muscle.bioRxiv : the preprint server for biology · 2026
    Article
  2. Review
  3. Review
  4. Review
  5. An In Vivo Model of Estrogen Supplementation Concerning the Expression of CaJournal of cardiovascular development and disease · 2024
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Heart Failure in Menopause: Treatment and New Approaches.International journal of molecular sciences · 2022
    Review
  14. Review
  15. Review
  16. Review
  17. GPER limits adverse changes to CaFrontiers in physiology · 2022
    Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Jeremiah Ong'achwa MachukiPhysiology Department, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.
Hong-Yuan ZhangPhysiology Department, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.
Juan GengPhysiology Department, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.
Lu FuPhysiology Department, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.
Gabriel Komla AdzikaPhysiology Department, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.
Lijuan WuPhysiology Department, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.
Wenkang ShangInstitute of Cardiovascular Disease Research, Xuzhou Medical University, Xuzhou, 221002, China.
Jinxia WuPhysiology Department, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.
Li KexuePhysiology Department, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.
Zhiwei ZhaoInstitute of Cardiovascular Disease Research, Xuzhou Medical University, Xuzhou, 221002, China.
Hong SunPhysiology Department, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China. sunh@xzhmu.edu.cn.ORCID 0000-0003-2135-3107
Xuzhou Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUNDS/

aimMale and female hearts have many structural and functional differences. Here, we investigated the role of estrogen (E2) in the mechanisms of sex differences in contraction through the cAMP-L-type Ca

methodsIsolated LV apical myocytes from male, female (Sham) and ovariectomised mice (OVX) were used to investigate contractility, Ca

resultsWe found that (1) intracellular cAMP, I

conclusionCollectively, these results demonstrate that E2 modulates the expression of genes related to the cAMP-LTCC pathway and contributes to sex differences in cardiac contraction and responses to stress. We also show that estrogen confers cardioprotection against cardiac stress by non-genomic acute signaling via GPR30.

Indexed as

Sex CharacteristicsAnimalsCalcium Channels, L-TypeCalcium Channels, T-TypeCalcium SignalingCardiotonic AgentsCyclic AMPCyclic Nucleotide Phosphodiesterases, Type 3Cyclic Nucleotide Phosphodiesterases, Type 4EstradiolFemaleGene Expression RegulationMaleMiceMyocardial ContractionMyocytes, CardiacAdrb1 protein, mouseADRB2 protein, mouseCalcium Channels, L-TypeCalcium Channels, T-TypeCardiotonic AgentsCyclic AMPCyclic Nucleotide Phosphodiesterases, Type 3Cyclic Nucleotide Phosphodiesterases, Type 4EstradiolGPER1 protein, mouseReceptors, Adrenergic, beta-1Receptors, Adrenergic, beta-2Receptors, EstrogenReceptors, G-Protein-Coupled17β-estradiolCa2+ transientsCardiac stressL-type Ca2+ channelPhosphodiesteraseSex differences in contractility

Identifiers

PMID30987657
PMCPMC6466778
OpenAlexW2941855960

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.