Evidence map›Paper›PMID 30987349›Full record

ArticleInternational journal of molecular sciences2019

Rab39a and Rab39b Display Different Intracellular Distribution and Function in Sphingolipids and Phospholipids Transport.

Julián Gambarte Tudela, Julio Buonfigli, Agustín Luján, Mariano Alonso Bivou, Ignacio Cebrián, Anahí Capmany, María Teresa Damiani

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 26 citations in OpenAlex.

  1. Inclusion Membrane Proteins ofMicroorganisms · 2026
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  9. Establishing the intracellular niche of obligate intracellular vacuolar pathogens.Frontiers in cellular and infection microbiology · 2023
    Review
  10. Article
  11. Article
  12. Review
  13. Rab GTPases in Parkinson's disease: a primer.Essays in biochemistry · 2021
    Article
  14. Drosophila Rab39 Attenuates Lysosomal Degradation.International journal of molecular sciences · 2021
    Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Endocytic Rabs Are Recruited to theFrontiers in cellular and infection microbiology · 2020
    Article
  20. The multiple functions of the numerousMicrobial cell (Graz, Austria) · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Julián Gambarte TudelaBiochemistry and Immunity Laboratory, School of Medicine, University of Cuyo, IMBECU-CONICET, Centro Universitario, Ciudad de Mendoza, Mendoza 5500, Argentina. jgambartetudela@gmail.com.
Julio BuonfigliBiochemistry and Immunity Laboratory, School of Medicine, University of Cuyo, IMBECU-CONICET, Centro Universitario, Ciudad de Mendoza, Mendoza 5500, Argentina. juliobuonfigli@yahoo.com.ar.
Agustín LujánBiochemistry and Immunity Laboratory, School of Medicine, University of Cuyo, IMBECU-CONICET, Centro Universitario, Ciudad de Mendoza, Mendoza 5500, Argentina. agustinlujan@hotmail.com.
Mariano Alonso BivouBiochemistry and Immunity Laboratory, School of Medicine, University of Cuyo, IMBECU-CONICET, Centro Universitario, Ciudad de Mendoza, Mendoza 5500, Argentina. malonsobivou@gmail.com.
Ignacio CebriánInstituto de Histología y Embriología de Mendoza (IHEM, Universidad Nacional de Cuyo, CONICET), Facultad de Ciencias Médicas, Mendoza 5500, Argentina. ignaciocebrian@yahoo.com.ar.
Anahí CapmanyBiochemistry and Immunity Laboratory, School of Medicine, University of Cuyo, IMBECU-CONICET, Centro Universitario, Ciudad de Mendoza, Mendoza 5500, Argentina. anahicapmany@hotmail.com.
María Teresa DamianiBiochemistry and Immunity Laboratory, School of Medicine, University of Cuyo, IMBECU-CONICET, Centro Universitario, Ciudad de Mendoza, Mendoza 5500, Argentina. meteresadamiani@gmail.com.
Universidad Nacional de Cuyo · ARConsejo Nacional de Investigaciones Científicas y Técnicas · ARInstituto de Medicina y Biología Experimental de Cuyo · AR

Funding

Argentine Science Agency PICT 2012-2116 and 2016-1851
6 · The paper itself

Abstract

Rab GTPases define the identity and destiny of vesicles. Some of these small GTPases present isoforms that are expressed differentially along developmental stages or in a tissue-specific manner, hence comparative analysis is difficult to achieve. Here, we describe the intracellular distribution and function in lipid transport of the poorly characterized Rab39 isoforms using typical cell biology experimental tools and new ones developed in our laboratory. We show that, despite their amino acid sequence similarity, Rab39a and Rab39b display non-overlapping intracellular distribution. Rab39a localizes in the late endocytic pathway, mainly at multivesicular bodies. In contrast, Rab39b distributes in the secretory network, at the endoplasmic reticulum/

Indexed as

Biological TransportChlamydia trachomatisEndoplasmic ReticulumGolgi ApparatusHeLa CellsHumansPhospholipidsrab GTP-Binding ProteinsSphingolipidsTime-Lapse ImagingPhospholipidsRAB39A protein, humanRab39B protein, humanrab GTP-Binding ProteinsSphingolipidsChlamydia trachomatisintracellular traffickinglipid transportRab39Rab isoformsRab proteinssmall GTPasessphingolipids

Identifiers

PMID30987349
PMCPMC6480249
OpenAlexW2932669774

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.