ArticleMolecules (Basel, Switzerland)2019
A Quantitative Tandem Mass Spectrometry and Scaled-Down QuEChERS Approach for Simultaneous Analysis of Pesticide Multiresidues in Human Urine.
Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Article
- SPE-UHPLC-MS/MS Method for Simultaneous Quantification of 50 Pesticide Biomarkers Across Nine Current-Use Chemical Classes in Human Urine.Journal of xenobiotics · 2026Article
- The analytical potential of the dry blood spot technique for pesticide biomonitoring - a review.Environmental monitoring and assessment · 2025Review
- Article
- Optimization of Ferimzone and Tricyclazole Analysis in Rice Straw Using QuEChERS Method and Its Application in UAV-Sprayed Residue Study.Foods (Basel, Switzerland) · 2024Article
- Simultaneous Analysis of 272 Pesticides in Agricultural Products by the QuEChERS Method and Gas Chromatography with Tandem Mass Spectrometry.Molecules (Basel, Switzerland) · 2024Article
- Determination of pesticide residues in urine by chromatography-mass spectrometry: methods and applications.Frontiers in public health · 2024Review
- Micronuclei, Pesticides, and Element Mixtures in Mining Contexts: The Hormetic Effect of Selenium.Toxics · 2023Article
- Factors Affecting Incurred Pesticide Extraction in Cereals.Molecules (Basel, Switzerland) · 2023Article
- LC-MS/MS Method Minimizing Matrix Effect for the Analysis of Bifenthrin and Butachlor in Chinese Chives and Its Application for Residual Study.Foods (Basel, Switzerland) · 2023Article
- Validation of a Multi-Residue Analysis Method for 287 Pesticides in Citrus Fruits Mandarin Orange and Grapefruit Using Liquid Chromatography-Tandem Mass Spectrometry.Foods (Basel, Switzerland) · 2022Article
- A method for the analysis of 121 multi-class environmental chemicals in urine by high-performance liquid chromatography-tandem mass spectrometry.Journal of chromatography. A · 2021Article
- Liquid Chromatography-Tandem Mass Spectrometry for the Simultaneous Analysis of 353 Pesticides in the Edible InsectMolecules (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Multiresidual pesticide determination in a biological sample is essential for an immediate decision and response related to various pesticide intoxications. A rapid and simultaneous analytical method for 260 pesticides in human urine was developed and validated using liquid chromatography-tandem mass spectrometry (LC-MS/MS). High speed positive/negative switching electrospray ionization (ESI) mode was used, and scheduled multiple reaction monitoring (MRM) was optimized. Three versions of scaled-down QuEChERS procedures were evaluated, and the procedure using non-buffer reagents (magnesium sulfate and sodium chloride) and excluding cleanup steps was selected for optimum pesticide extraction. The limit of quantitation (LOQ) in this methodology was 10 ng/mL for each target pesticide, and correlation coefficient (r²) values of calibration curves were ≥0.988 (linearity range; 10-250 ng/mL). In accuracy and precision tests, the relative error ranges were -18.4% to 19.5%, with relative standard deviation (RSD) 2.1%-19.9% at an LOQ level (10 ng/mL), and -14.7% to 14.9% (RSD; 0.6%-14.9%) at higher concentrations (50, 150, and 250 ng/mL). Recovery range was 54.2%-113.9% (RSD; 0.3%-20.0%), and the soft matrix effect (range; -20% to 20%) was observed in 75.4% of target pesticides. The established bioanalytical methods are sufficient for application to biomonitoring in agricultural exposures and applicable in the forensic and clinic.
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