Evidence map›Paper›PMID 30987327›Full record

ArticleBiosensors2019

Specific and Generic Immunorecognition of Glycopeptide Antibiotics Promoted by Unique and Multiple Orientations of Hapten.

Maksim A Burkin, Inna A Galvidis, Sergei A Eremin

Open access · goldAbstract read
In one paragraph

Article in Biosensors, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Maksim A BurkinImmunology Department, I. Mechnikov Research Institute for Vaccines and Sera, 105064 Moscow, Russia. burma68@yandex.ru.ORCID 0000-0003-1946-430X
Inna A GalvidisImmunology Department, I. Mechnikov Research Institute for Vaccines and Sera, 105064 Moscow, Russia. galvidis@yandex.ru.ORCID 0000-0001-6442-7343
Sergei A EreminFaculty of Chemistry, M. V. Lomonosov MSU, Leninsky Gory, 1, 119991 Moscow, Russia. eremin_sergei@hotmail.com.ORCID 0000-0002-6936-0720
Research Institute of Vaccines and Sera. Mechnikov of the Russian Academy of Medical Sciences · RULomonosov Moscow State University · RU

Funding

Ministry of Education and Science of the Russian Federation RFMEFI60417X0198
6 · The paper itself

Abstract

Conjugation chemistry does not always provide adequate spatial orientation of hapten in immunogens for the best presentation of generic or individual epitopes. In the present study, the influence of unique and multiple orientations of immunizing hapten on the immune response repertoire was compared to select generic recognition system. The glycopeptides, teicoplanin (TPL) and ristomycin (RSM), were conjugated to BSA to produce immunogens with unique and multiple orientations of haptens. Polyclonal antibodies generated against TPL conjugated through a single site were of uniform specificity and demonstrated selective TPL recognition, regardless of the coating conjugates design. The sensitivity (IC

Indexed as

Biosensing TechniquesAnimalsAnti-Bacterial AgentsEnzyme-Linked Immunosorbent AssayGlycopeptidesHaptensMolecular StructureRabbitsAnti-Bacterial AgentsGlycopeptidesHaptensantibody repertoireeremomycingroup recognitionhapten conjugate designristomycinteicoplaninvancomycin

Identifiers

PMID30987327
PMCPMC6627899
OpenAlexW2928009378

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.