Evidence map›Paper›PMID 30987307›Full record

ArticleNanomaterials (Basel, Switzerland)2019

Remote Magnetic Control of Autophagy in Mouse B-Lymphoma Cells with Iron Oxide Nanoparticles.

You-Rong Lin, Chia-Hao Chan, Hui-Ting Lee, Sheng-Jen Cheng, Jia-Wei Yang, Shing-Jyh Chang, Shien-Fong Lin, Guan-Yu Chen

Abstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

You-Rong LinInstitute of Biomedical Engineering, College of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu 30010, Taiwan. yoronglin@gmail.com.ORCID 0000-0002-7815-5913
Chia-Hao ChanInstitute of Biomedical Engineering, College of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu 30010, Taiwan. chchan0430@gmail.com.
Hui-Ting LeeDivision of Allergy, Immunology and Rheumatology, MacKay Memorial Hospital, Taipei 10491, Taiwan. htlee1228@gmail.com.
Sheng-Jen ChengInstitute of Biomedical Engineering, College of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu 30010, Taiwan. shengjen@nctu.edu.tw.
Jia-Wei YangInstitute of Biomedical Engineering, College of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu 30010, Taiwan. jiawei@nctu.edu.tw.
Shing-Jyh ChangGynecologic Oncology Section Department of Obstetrics and Gynecology, Hsinchu MacKay Memorial Hospital, Hsinchu 300, Taiwan. justine3@ms8.hinet.net.
Shien-Fong LinInstitute of Biomedical Engineering, College of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu 30010, Taiwan. linsf5402@nctu.edu.tw.
Guan-Yu ChenInstitute of Biomedical Engineering, College of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu 30010, Taiwan. guanyu@nctu.edu.tw.ORCID 0000-0002-3443-7943

Funding

Hsinchu MacKay Memorial Hospital MMH-CT-10704Ministry of Science and Technology MOST 105-2628-B-009-001-MY3, MOST 106-EPA-F006-001, MOST 107-2622-E-009-023-CC1National Chiao Tung University 106W970, 107W970National Health Research Institutes NHRI-EX107-10714EC
6 · The paper itself

Abstract

Autophagy is the spontaneous degradation of intracellular proteins and organelles in response to nutrient deprivation. The phagocytosis of iron oxide nanoparticles (IONPs) results in intracellular degradation that can be exploited for use in cancer treatment. Non-invasive magnetic control has emerged as an important technology, with breakthroughs achieved in areas such as magneto-thermal therapy and drug delivery. This study aimed to regulate autophagy in mouse B-lymphoma cells (A20) through the incorporation of IONPs-quantum dots (QDs). We hypothesized that with the application of an external magnetic field after phagocytosis of IONPs-QDs, autophagy of intracellular IONPs-QDs could be regulated in a non-invasive manner and subsequently modulate the regulation of inflammatory responses. The potential of this approach as a cancer treatment method was explored. The application of IONPs and an external magnetic force enabled the non-invasive regulation of cell autophagy and modulation of the self-regulatory function of cells. The combination of non-invasive magnetic fields and nanotechnology could provide a new approach to cancer treatment.

Indexed as

autophagyiron oxide nanoparticlemagnetic fieldproinflammatory cytokine

Identifiers

PMID30987307
PMCPMC6524120

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.