Evidence map›Paper›PMID 30987252›Full record

ArticleMolecules (Basel, Switzerland)2019

High Consistency of Structure-Based Design and X-Ray Crystallography: Design, Synthesis, Kinetic Evaluation and Crystallographic Binding Mode Determination of Biphenyl-

Thomas Fischer, Symeon M Koulas, Anastasia S Tsagkarakou, Efthimios Kyriakis, George A Stravodimos, Vassiliki T Skamnaki, Panagiota G V Liggri, Spyros E Zographos, Rainer Riedl, Demetres D Leonidas

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Thomas FischerInstitute of Chemistry and Biotechnology, Center of Organic and Medicinal Chemistry, Zurich University of Applied Sciences, Einsiedlerstrasse 31, 8820 Wädenswil, Switzerland. thomas.fischer@zhaw.ch.
Symeon M KoulasDepartment of Biochemistry and Biotechnology, University of Thessaly, Biopolis, 41500 Larissa, Greece. sym.koulas@gmail.com.
Anastasia S TsagkarakouDepartment of Biochemistry and Biotechnology, University of Thessaly, Biopolis, 41500 Larissa, Greece. anastasiatsagk@hotmail.com.ORCID 0000-0003-1723-7840
Efthimios KyriakisDepartment of Biochemistry and Biotechnology, University of Thessaly, Biopolis, 41500 Larissa, Greece. kyriakis.ef@gmail.com.
George A StravodimosDepartment of Biochemistry and Biotechnology, University of Thessaly, Biopolis, 41500 Larissa, Greece. stravodimos@windowslive.com.
Vassiliki T SkamnakiDepartment of Biochemistry and Biotechnology, University of Thessaly, Biopolis, 41500 Larissa, Greece. vskamnaki@bio.uth.gr.
Panagiota G V LiggriDepartment of Biochemistry and Biotechnology, University of Thessaly, Biopolis, 41500 Larissa, Greece. b_liggri@windowslive.com.
Spyros E ZographosInstitute of Biology, Pharmaceutical Chemistry and Biotechnology, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, 11635 Athens, Greece. sez@eie.gr.
Rainer RiedlInstitute of Chemistry and Biotechnology, Center of Organic and Medicinal Chemistry, Zurich University of Applied Sciences, Einsiedlerstrasse 31, 8820 Wädenswil, Switzerland. rainer.riedl@zhaw.ch.ORCID 0000-0003-2534-1963
Demetres D LeonidasDepartment of Biochemistry and Biotechnology, University of Thessaly, Biopolis, 41500 Larissa, Greece. ddleonidas@bio.uth.gr.ORCID 0000-0002-3874-2523

Funding

Department of Biochemistry and Biotechnology, University of Thessaly Application of Molecular Biology-Molecular Genetics-Molecular MarkersEuropean Social Fund "Human Resources Development, Education and Lifelong Learning" in the context of the project "Strengthening Human Resources Research Potential via Doctorate Research" (MIS-5000432)ZHAW Zurich University of Applied Sciences Internal funding
6 · The paper itself

Abstract

Structure-based design and synthesis of two biphenyl-

Indexed as

Drug DesignQuantitative Structure-Activity RelationshipBinding SitesCatalytic DomainChemistry Techniques, SyntheticCrystallography, X-RayEnzyme InhibitorsGlucosamineGlycogen PhosphorylaseHumansHydrogen BondingModels, MolecularProtein BindingEnzyme InhibitorsglucopyranosylamineGlucosamineGlycogen Phosphorylaseglycogen metabolismglycogen phosphorylase inhibitorN-acyl-β-d-glucopyranosylaminestructure-based designtype 2 diabetesX-ray crystallography

Identifiers

PMID30987252
PMCPMC6479789

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.