ArticleAnimals : an open access journal from MDPI2019
Grading Distress of Different Animal Models for Gastrointestinal Diseases Based on Plasma Corticosterone Kinetics.
Article in Animals : an open access journal from MDPI, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 20 citations in OpenAlex.
- The Predictive Accuracy of Methods Commonly Used for Evaluating Animal Distress.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Enhancing Preclinical Rigor: Evaluating Robustness and Numerical Stability in a Chronic Pancreatitis Mouse Model.Annals of the New York Academy of Sciences · 2026Article
- Burrowing Behavior as Robust Parameter for Early Humane Endpoint Determination in Murine Models for Pancreatic Cancer.Animals : an open access journal from MDPI · 2025Article
- Peripheral contributions to resting state brain dynamics.Nature communications · 2024Article
- Sex Matters-Insights from Testing Drug Efficacy in an Animal Model of Pancreatic Cancer.Cancers · 2024Article
- Robustness of a multivariate composite score when evaluating distress of animal models for gastrointestinal diseases.Scientific reports · 2023Article
- Generalizability, Robustness and Replicability When Evaluating Wellbeing of Laboratory Mice with Various Methods.Animals : an open access journal from MDPI · 2022Article
- RELSA-A multidimensional procedure for the comparative assessment of well-being and the quantitative determination of severity in experimental procedures.Frontiers in veterinary science · 2022Article
- Distress Analysis of Mice with Cervical Arteriovenous Fistulas.Animals : an open access journal from MDPI · 2021Article
- Diagnostic Ability of Methods Depicting Distress of Tumor-Bearing Mice.Animals : an open access journal from MDPI · 2021Article
- Voluntary wheel running behaviour as a tool to assess the severity in a mouse pancreatic cancer model.PloS one · 2021Article
- Analysis of Pain and Analgesia Protocols in Acute Cerulein-Induced Pancreatitis in Male C57BL/6 Mice.Frontiers in physiology · 2021Article
- Analysis of Animal Well-Being When Supplementing Drinking Water with Tramadol or Metamizole during Chronic Pancreatitis.Animals : an open access journal from MDPI · 2020Article
- Comparing distress of mouse models for liver damage.Scientific reports · 2020Article
- Benefits of non-invasive methods compared to telemetry for distress analysis in a murine model of pancreatic cancer.Journal of advanced research · 2020Article
- A novel multi-parametric analysis of non-invasive methods to assess animal distress during chronic pancreatitis.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Comparative studies for evaluating distress in established animal models are still rare. However, this issue is becoming more important as a consequence of worldwide appreciation of animal welfare. One good parameter for evaluating distress is the quantification of corticosterone. We hypothesized that not just the absolute value but also the duration of increased corticosterone concentration in the blood is an important aspect for evaluating animal distress. Therefore, we analyzed plasma corticosterone concentrations 30, 60, 120, and 240 min after induction of pancreatitis by cerulein, liver damage by carbon tetrachloride, liver damage by bile duct ligation, and after orthotopic injection of pancreatic cancer cells. We also evaluated corticosterone kinetics after injection of distinct carrier substances. Compared to phosphate buffered saline, dimethyl sulfoxide leads to dose-dependent higher and longer-lasting circulating corticosterone concentrations. In all disease models, we observed significantly increased corticosterone concentration 30 min after stress induction. However, the corticosterone kinetics differed among the animal models. Both the absolute value of corticosterone concentration and the duration correlated positively with the quantification of animal distress by a score sheet. This suggests that both variables of corticosterone kinetics might provide a solid basis for comparing and grading distress of different animal models
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.