Evidence map›Paper›PMID 30987218›Full record

Trial reportCells2019

Time- and Kellgren⁻Lawrence Grade-Dependent Changes in Intra-Articularly Transplanted Stromal Vascular Fraction in Osteoarthritic Patients.

Tung Dang Xuan Tran, Chi-Ming Wu, Navneet Kumar Dubey, Yue-Hua Deng, Chun-Wei Su, Tu Thanh Pham, Phuong Bich Thi Le, Piero Sestili, Win-Ping Deng

Open access · goldAbstract readClinical Trial, Phase IClinical Trial, Phase II
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 5 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 5 syntheses or guidelines pooled it, 60 citations in OpenAlex.

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  15. Efficacy and safety of mesenchymal stem cell injections for knee osteoarthritis: A systematic review and meta-analysis.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Tung Dang Xuan TranSchool of Dentistry, Taipei Medical University, Taipei 11031, Taiwan. d204105004@tmu.edu.tw.
Chi-Ming WuGraduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan. chiming.wu@jade-dental.com.tw.
Navneet Kumar DubeyGraduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan. bioengineer.nkd@gmail.com.
Yue-Hua DengDepartment of Life Science, Fu Jen Catholic University, New Taipei City 242, Taiwan. yuehuahua828@gmail.com.
Chun-Wei SuStem Cell Research Center, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan. q7s5w8a4@gmail.com.
Tu Thanh PhamVan Hanh Stem Cells Unit, Van Hanh Hospital, Ho Chi Minh City 700000, Vietnam. thanhtuvanhanh@gmail.com.
Phuong Bich Thi LeDepartment of Pulmonary Medicine, Vietnam Military Medical Academy, Ha Noi 12108, Vietnam. drbphuong@gmail.com.
Piero SestiliDipartimento di Scienze Biomolecolari, Università degli Studi di Urbino Carlo Bo Via "I Maggetti" 26, 61029 Urbino, Italy. piero.sestili@uniurb.it.
Win-Ping DengSchool of Dentistry, Taipei Medical University, Taipei 11031, Taiwan. wpdeng@tmu.edu.tw.
Taipei Medical University · TWPham Ngoc Thach Hospital · VNFu Jen Catholic University · TWUniversity of Urbino · ITVietnam Military Medical University · VN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Knee osteoarthritis (OA) is one of the most prevalent disorders in elderly population. Among various therapeutic alternatives, we employed stromal vascular fraction (SVF), a heterogeneous cell population, to regenerate damaged knee cartilage. OA patients were classified on the basis of age, gender, body mass index (BMI), and x-ray-derived Kellgren-Lawrence (KL) grade. They were treated with SVF and followed-up for 24 months. Visual analogue scale (VAS) and Western Ontario and McMaster Universities Osteoarthritis (WOMAC) Index were used to determine treatment efficacy. Cartilage healing was assessed using the MRI-based Outerbridge score (OS) and evaluation of bone marrow edema (BME) lesions, while a placebo group was used as a control. Time- and KL-dependent changes were also monitored. We observed a decreasing trend in VAS score and WOMAC index in the SVF-treated group up to 24 months, as compared with the placebo group. Besides, a significant increase and decrease in Lysholm and OS, respectively, were observed in the treatment group. Compared with the values before treatment, the greatly reduced WOMAC scores of KL3 than KL2 groups at 24 months, indicate more improvement in the KL3 group. Highly decreased BME in the treated group was also noted. In conclusion, the SVF therapy is effective in the recovery of OA patients of KL3 grade in 24 months.

Indexed as

Stem Cell TransplantationBone and BonesCartilageEdemaFemaleHumansInjections, Intra-ArticularKnee JointMagnetic Resonance ImagingMaleMiddle AgedOsteoarthritis, KneeStromal CellsTreatment OutcomeVisual Analog ScaleWound HealingBMEKL gradeknee osteoarthritis (OA)MRIOSstromal vascular fraction (SVF)VASWOMAC

Identifiers

PMID30987218
PMCPMC6523621
OpenAlexW2929526016

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.