Evidence map›Paper›PMID 30987121›Full record

ArticleMolecules (Basel, Switzerland)2019

Derivatives of the β-Crinane Amaryllidaceae Alkaloid Haemanthamine as Multi-Target Directed Ligands for Alzheimer's Disease.

Eliška Kohelová, Rozálie Peřinová, Negar Maafi, Jan Korábečný, Daniela Hulcová, Jana Maříková, Tomáš Kučera, Loreto Martínez González, Martina Hrabinova, Katarina Vorčáková and 4 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
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  7. Synthesis of New 3-Arylcoumarins BearingFrontiers in chemistry · 2021
    Article
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  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 3 countries.

Eliška KohelováADINACO Research Group, Department of Pharmaceutical Botany, Faculty of Pharmacy, Charles University, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic. kohelove@faf.cuni.cz.
Rozálie PeřinováADINACO Research Group, Department of Pharmaceutical Botany, Faculty of Pharmacy, Charles University, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic. perinovr@faf.cuni.cz.
Negar MaafiADINACO Research Group, Department of Pharmaceutical Botany, Faculty of Pharmacy, Charles University, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic. negarm@faf.cuni.cz.
Jan KorábečnýDepartment of Toxicoloxy and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Třebešská 1575, 500 05 Hradec Králové, Czech Republic. korabecny.jan1@gmail.com.ORCID 0000-0001-6977-7596
Daniela HulcováADINACO Research Group, Department of Pharmaceutical Botany, Faculty of Pharmacy, Charles University, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic. hulcovd@faf.cuni.cz.
Jana MaříkováDepartment of Organic and Bioorganic Chemistry, Faculty of Pharmacy, Charles University, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic. marikoj2@faf.cuni.cz.
Tomáš KučeraDepartment of Toxicoloxy and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Třebešská 1575, 500 05 Hradec Králové, Czech Republic. tomas.kucera2@unob.cz.ORCID 0000-0001-6650-1738
Loreto Martínez GonzálezCentro de Investigaciones Biológicas-CSIC, Avenida Ramiro de Maeztu 9, 28040 Madrid, Spain. loretomg@cib.csic.es.
Martina HrabinovaDepartment of Toxicoloxy and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Třebešská 1575, 500 05 Hradec Králové, Czech Republic. hrabinova@pmfhk.cz.
Katarina VorčákováDeaprtment of Biological and Biochemical Sciences, Faculty of Chemical Technology, University of Pardubice, Studentská 95, 532 10 Pardubice, Czech Republic. katarina.vorcakova@upce.cz.ORCID 0000-0001-6961-6151
Lucie NovákováDepartment of Analytical Chemistry, Faculty of Pharmacy, Charles University, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic. novakoval@faf.cuni.cz.
Angela De SimoneDepartment for Life Quality Studies, University of Bologna, Corso D'Augusto 237, 47921 Rimini, Italy. angela.desimone2@unibo.it.
Radim HavelekDepartment of Medicinal Biochemistry, Faculty of Medicine, Charles University, Zborovská 2089, 500 03 Hradec Králové, Czech Republic. havelekr@lfhk.cuni.cz.
Lucie CahlíkováADINACO Research Group, Department of Pharmaceutical Botany, Faculty of Pharmacy, Charles University, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic. cahlikova@faf.cuni.cz.ORCID 0000-0002-1555-8870
Charles University · CZUniversity of Defence · CZCentro de Investigaciones Biológicas Margarita Salas · ESUniversity Hospital Hradec Králové · CZUniversity of Bologna · ITUniversity of Pardubice · CZ

Funding

European Union CZ.02.1.01/0.0/0.0/18_069/0010046University Hospital, Hradec Králové 00179906Univerzita Karlova v Praze GA UK Nr. 178518, SVV UK 260 412; 260 401; Progres/UK Q40 and Q42
6 · The paper itself

Abstract

Twelve derivatives

Indexed as

Alzheimer DiseaseAmaryllidaceaeAmaryllidaceae AlkaloidsBlood-Brain BarrierGlycogen Synthase Kinase 3 betaHumansLigandsModels, MolecularMolecular ConformationMolecular Docking SimulationMolecular StructurePermeabilityPhenanthridinesStructure-Activity RelationshipAmaryllidaceae AlkaloidsGlycogen Synthase Kinase 3 betahemanthamineLigandsPhenanthridinesacetylcholinesteraseAlzheimer’s diseaseAmaryllidaceaebutyrylcholinesterasedocking studiesglycogen synthase kinase-3β inhibitionhaemanthamine

Identifiers

PMID30987121
PMCPMC6480460
OpenAlexW2932894082

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.